Medication combination for hepatoma and pancreatic cancer and preparation protocol

ABSTRACT

This invention discloses a medication combination, consisting of Baizhu, Danggui, Hanxincao, Huotanmucao, Ainaxiang, Shuodiao, Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren, Nuzhenzi, Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi, Banxia, and Fuling for treating hepatoma and pancreatic cancer, modifies the conventional extraction procedure and is characterized by the inclusion of Poria, which possesses an anti-tumor ability, as the excipient. This medication combination is based on a novel and continuous theory for cancer therapy and traditional Chinese medicine theories. It has made use of nature and characteristics of those abovementioned medications to lead and change the environments for cancer growth inside the patients&#39; bodies, and then to result in the discomfort and revulsion of cancer cells in such environments. In another word, this medication combination alters the cancer environment via pharmacology and exerts a certain extent of anti-tumor effect on the primary or metastatic hepatoma and pancreatic cancer.

FIELD OF THE INVENTION

[0001] The present invention relates to a medication combination, consisting of Baizhu, Danggui, Hanxincao, Huotanmucao, Ainaxiang, Shuodiao, Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren, Nuzhenzi, Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi, Banxia, and Fuling for treating hepatoma and pancreatic cancer.

BACKGROUND OF THE INVENTION

[0002] The progression of cancer therapy has been idled in the perplexity of anti-tumor with lack of effective medication for internal use. The efficiencies of expedient treatments, such as thrombosis, radiation therapy, and chemotherapy were limited. Meanwhile, those extreme, harsh and complicated therapy courses have made patients suffered from horrible pains. With a doubtful presupposition of killing cancer cells, the neglect on the pathological deterioration of other areas or tissues has led to hideous hypersensitive reactions or dosage dependency.

[0003] Unfortunately, cancer researches have been restrained inside a fixed model. The idea of anticancer being equal to cancer curing has been wrongly believed. All beautiful and attractive theories should not be ensured before accomplishing and should be treated as hypothesis. Inapplicable or undesirable presumed theories must be with flaws or doubts. Therefore, it is urgently necessary to break this fixed model and present a novel idea, theory or remedy. Anticancer research in China has reached a certain level and more than 300 medications have been proven valuable through animal tests for anticancer, however, none of these medications could effectively treat cancers if used solely. The ultimate cause should be investigated (please refer to Chapter 12 in the new way to treat cancer in the 21^(th) century, a book of this Inventor).

[0004] With the advantages of ample resources of Chinese medicine and policy encourage, anticancer and cancer curing business in this countries have progressed enormously with many publications on highly effective medications, which are however not been applied by the industry. This may be due to the conventional descriptions on “discrimination of symptoms and discussion of treatments” were not widely understood and accepted.

SUMMARY OF THE INVENTION

[0005] The main aim of this invention is to present a medication combination for treating hepatoma and pancreatic cancer and to expand a new treatment of Chinese medicines by novel and continuous theories and remedies. Based on implication of “discrimination of symptoms and discussion of treatments”, precise and simple description of “six elements”, which is the composition of organism, will be widely accepted and blended into the medical trend to create a new way of Chinese medicines to cure cancers.

[0006] Another aim of this invention is to present a medication combination for treating hepatoma and pancreatic cancer with a convenient way of internal use, which could enhance the efficiency of curing cancer, reduce the medical cost and therefore, benefit overall cancer patients.

[0007] To achieve the abovementioned goals, the medication combination for treating hepatoma and pancreatic cancer comprises:

[0008] (a) one or more medications selected from the group consisting of Fuling, Baizhu and Danggui for improving the function of pancreas and connections to other organs;

[0009] (b) one or more medications selected from the group consisting of Hanxincao, Huotanmucao, Ainaxiang and Shuodiao fro eliminating barriers in permeability of the portal vein, liver and pancreas to decrease the pressure of the portal vein;

[0010] (c) one or more medications selected from the group consisting of Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren and Nuzhenzi for enhancing the defensive function, lymphatic circulation, and immunity, and

[0011] (d) one or more medications selected from the group consisting of Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi and Banxia for pathological amendments specific for hepatoma and pancreatic cancer.

[0012] The novel theory, pharmacology, pathology of hepatoma and pancreatic cancer, clinical trials and statistics of efficiency are described as follows.

DETAIL DESCRIPTION OF THE INVENTION

[0013] The Novel Theory

[0014] The traditional theories of anticancer could not break through the bottleneck of cancer curing nor enhance the efficiency. Therefore, this inventor has created continuous theories for curing cancer and to achieve the expected efficiency. To simply describe, the novel theories are sequentially “A theory on birth, growth, aging and death of a creature”, “A theory on the developing environment of a creature”, “A theory on surrounding pathology of cancer”, and “A theory on variation of six elements in the cancer”, which is a part of “A theory on six elements”. These four theories are extension and innovation of viewpoints on Chinese medicine from all past dynasties. They are uniquely integrated with bio-philosophy and apply the characters of the ancient philosopher, Lao-Tzu (about 580 B.C.) to generate a precise and acceptable description.

[0015] Firstly in “A theory on birth, growth, aging and death of a creature” (please refer to Chapter 2 in the new way to treat cancer in the 21^(th) century, a book of this Inventor), it was stated that all normal creatures must go through stages of birth (reproduction), growth, aging and weakness, and death. Since cancer cells are organisms, they are not exceptional and also have limitations of weakness and death. If there is any method or medication able to alleviate the production and growth of cancer cells as well as promote the weakness and death, cancer will be curable without “resistance, killing, and extermination”.

[0016] To achieve assumed targets abovementioned, the real situation, internal environment and causes for alternation for birth, growth, aging and death have to be understood in advance. Therefore, “A theory on the developing environment of a creature” (please refer to Chapter 1 in the new way to treat cancer in the 21^(th) century, a book of this Inventor) can be apprehended to have a certain extent of environmental adaptation, that is, to reproduce and grow in a nice environment but weak and die in a repulsive environment. Among these, the most valuable finding is that the formation of environment is totally depended on the nature, status and characteristics of materials. The normal human body is not a suitable environment for growth and activity of cancer cells. However, after a long-term influence by the nature, characteristic and direction of abnormal materials, the patient's body has become a suitable environment for cancer cells to survive, reproduce and growth, that is, a paradise for cancer cells. This is the philosophy of cancer formation. It should be noted that medication is one kind of material. The nature, characteristic and direction of medication are equal to the texture, smell, taste, and ingredient, which are overall pharmacology. By choosing the best material and applying its nature, characteristic and direction, another environment, which cancer cells are difficult to adapt and repulsive, could be formed in the patient's body to retard the reproduction and growth as well as to promote the weakness and death of cancer cells and therefore, cancers could be easily cured.

[0017] A constitution with an environment, which is suitable for the reproduction, survive and growth of cancer cells, is different from that of normal and therefore been nominated as “an unique constitution of cancer”. After thoroughly examinations and experiments, it has been understood basically to form “A theory on surrounding pathology of cancer” (please refer to Chapter 3 and p111 of appendix 4 in the new way to treat cancer in the 21^(th) century, a book of this Inventor). Such fixed surrounding pathology, present in all types of cancers, have 3 abnormal pathological findings, including reduced function of pancreas with poor connection to other organs, poor permeability of hepatic circulation and pancreas with generally high pressure, and malfunction of defensive tissues and lymphatic circulation. The environment with such 3 pathological findings is a suitable environment for cancer cells.

[0018] The conventional theories such as “discrimination of symptoms and discussion of treatments”, “wind, cold, hot, dry, anger six wicked elements”, “negative and positive, false or true, outside and inside”, are not commonly recognized by ordinary people except scholars of Chinese medicine. These outstanding practical theories are indispensable in Chinese medicine, therefore, the inventor has derived “A theory on variation of six elements in the cancer” from “A theory on six elements” to make a concise and easy description. This philosophic theory, originally about the constitution of creatures, can be applied in the treatment and even in the cancer curing.

[0019] Similar to other creatures, the elements for constituting the cancer environment are energy (one), space (sky), essence (earth), humidity (water), air (wind), and temperature (fire). These are “six elements” for creature constitution. “Energy” refers the natural vitality, “space” refers the size of interspace, “essence” refers the real substance, “humidity” refers the amount of liquid water, “air” refers the ingredient in the air and “temperature” refers cold or hot. These six elements can be present by the conditions of inside, outside, sites, organs, and tissues of human body. By using the circulation of blood inside the human body as an example to describe the essence and combination of these six elements, the vascular wall is the “essence”, vascular cavity or places that blood can permeate is the “space”, the blood flow is based on “energy”, and blood is a combination of elements, including humidity (water), essence (blood cells), air (oxygen and carbon dioxide), temperature (cold and hot).

[0020] Inside the human body, the key point for condition observation on tissues is the “alternation”, that is different from the ordinary and normal, which is pathological finding, for examples, local inflammation, redness and swelling, hyperemia, pain, higher temperature of hepatic lobes, mal-metabolism of water and higher temperature in pancreas, less movement in the intestines and complication in urination and excretion. All pathological variations could be traced to the root by description of six elements. As for the diagnosis and observation, “observation, listen, smell, question, and feeling the pulse” of Chinese medicine and X ray, scan, and all kinds of tests, as well as patient history and experiences can be employed. This invention is based on surrounding pathology and real condition of variation in these six elements to choose a best medication combination for treating hepatoma and pancreatic cancer. The nature, characteristic and direction of this combination will form an environment, which cancer cells hate to achieve the objective that cancer cells stop growing and then die.

[0021] There are indeed a few mistakes and confusion in the conventional theories of Chinese medicine. Spleen referred in Chinese medicine, not as the spleen in modern anatomy, is as pancreas in this description (please refer to “spleen is not the spleen” in appendix 2, in the book writing by the inventor). In addition, fire should be referred as temperature, instead of heat, and therefore, can be distinguished as cold and hot. Water is referred as humidity and classified as dry and wet. All materials or differentiation of materials have both positive and negative directions. The abovementioned is only for the correctness of this description.

[0022] As for the close relationships between environment and cancers, a few findings have been revealed by numerous studies. However, due to the limitation of certain objective conditions, these findings could not be further investigated. For examples, it was found that cancer cells are prone to anaerobic metabolism. The product of this metabolism, lactic acid, will contribute to form an acidic environment and therefore, is beneficial to increase the activity of β-glycosidase. This will promote the degradation of amygdalin into hydrocyanic acid and benzaldehyde and then to exert more powerful action against cancer.

[0023] In addition, as indicated in “Pharmacology of Chinese medicine” of Yi-Kui Lee, dilute alcohol- or water-extracts of banxia can significantly inhibit the growth of HCA, S180 and HeLa cells in animal models. In the aspect of mechanisms of such inhibition, as referred in “Pharmacology and clinical application of Chinese medicine” of Shou-Yi Liu, Banxia is able to significantly reduce the secretion of stomach acid, reduce the acidity of free acid and total acid and also inhibit the activity of pepsin.

[0024] From abovementioned studies, it was found that characteristics including anaerobic degradation, acidic tendency, higher acidity in free acid and total acid are present in the experimental environment resistant to cancer. The inhibitory activity and resistance to cancer of amygdalin, dilute alcohol- or water-extracts of banxia is based on the utilization of known environment or alteration of original environment to generate a cause and effect relationship, which is also the pioneer viewpoint of the theory of this invention. However, the human-cancer environment formed by persistent material situation is not that simple.

[0025] Pathological Anatomy

[0026] Types of primary hepatoma include a big and developing type with a single cancerous nodule (grain in liver), a nodal type with dispersed cancer nodules of various sizes, a fine type with numerous of micro nodules infiltrating the whole liver, a intrahepatic bile duct type with tumors inside bile duct. In the case of secondary hepatoma, numerous nodules of various sizes result in enlargement of liver with a hard and gray-yellowish cross-section. After maturation, necrosis occurs in the middle of tumor tissue and a hemispheric bulge occurs in the near surface with a tumor navel at the apex.

[0027] Over half of pancreatic cancers occur at hepatopancreticae, mostly at the epithelium of pancreas duct and sometimes at the epithelium of a lobule. Scirrhosity is the most common and followed in sequential by medullary cancer and column epithelial cancer. Glioma is the less.

[0028] Symptoms

[0029] The main complaint of hepatoma, in general, is the local swelling, hard and pain of right costal and liver region, stomach and abdomen. Based on the severity, the right costal and liver area may be stretched tight, swollen, hard and even obviously enlarged and harden. Such symptoms may be extended to the pit of the stomach or right abdomen. Various sizes of nodules, which are hard and tender, are touchable at the surface or bottom of liver. If severe, swollen bulk can be observed obviously and hard as rock. The severity of pain can be distinguished as tender, occasional, and dull, which may progress to become stuffy, persistent or sharp pain. Due to the tumor site, in addition, pain can be at both sides of costa and back and may extend to the right shoulder and arm. Distention of Stomach or abdomen without reasons may be due to the high pressure of hepatic circulation, which is the result of pancreatic hypofunction and poor permeability of liver. These may also induce the enlargement of spleen, bleeding of digestive tracts in the side circulation, dilation of subcutaneous veins, production of ascites, edema of the shin, inflammation of lymph nodes in clavicle, intermittent fever. The blood related symptoms include erythropenia, transformation and leukocytosis. In addition, symptoms also include darken, dryness, and jaundice of skin.

[0030] The main symptoms of pancreatic cancer include tenderness or persistent pain at the tip of stomach, pain and swelling at the right costal region, shoulder and arm, acid or salty saliva generated on the surface of tongue, which is a characteristic of pancreas condition. Tumors at the epithelium of pancreas lobe are more persistent and progressive, and could cause a person pale and skinny without appetite in a short period. Persistent jaundice commonly occurred with pancreatic cancer, as well as fever from bacterial infection. Most of survivors are complicated with symptoms of hepatoma.

[0031] Formulation

[0032] This medicine combination, for treating hepatoma and pancreatic cancer, consists of following powder, concentrated and extracted, at a fixed ratio. Fuling powder, included in each preparation, is employed to be the excipient. Concentrated Fuling excipient Malan 6-10% Qianhu 3-7% Baizhu 3-7% Ludou 5-9% Jiatonghao 3-7% Danggui 3-7% Canger 3-7% Yinchenhao 3-7% Hanxincao 4-8% Daqinggen 4-8% Yujin 3-7% Huotan- 2-6% Banbianlian 3-7% Zhishi 2-6% mucao Ainaxiang 2-6% Xingren 2-6% Banxia 2-6% Shuodiao 5-9% Nuzhenzi 4-8% Total

[0033] These ingredients in each medication can be included or not included, as well as be augmented or subtracted, based on the small pathological variation among patients. The best configuration is 5% of Baizhu, 5% of Danggui, 6% of Hanxincao, 4% of Huotanmucao, 4% of Ainaxiang, 7% of Shuodiao, 8% of Malan, 7% of Ludou, 5% of Canger, 6% of Daqinggen, 5% of Banbianlian, 4% of Xingren, 6% of Nuzhenzi, 5% of Qianhu, 5% of Jiatonghao, 5% of Yinchenhao, 5% of Yujin, 5% of Zhishi, 4% of Banxia to make a total of 100%.

[0034] Pharmacological Description

[0035] Pharmacological description, as shown in pharmacological data sheet of each ingredient, is emphasized on improvement of 3 aspects in surrounding pathology, including improvement in the function of pancreas and connections to other organs, elimination of the barriers in permeability of the portal vein, liver and pancreas to decrease the pressure in the portal vein, enhancement in the defensive function, lymphatic circulation, and immunity, as well as pathological amendments specific for hepatoma and pancreatic cancer. Other compatible cancer treatments are also described.

[0036] The following descriptions are aimed on the main pathological symptoms of hepatoma and pancreatic cancer, as well as the pharmacology.

[0037] The pathology of swelling and pain in the major symptoms of hepatoma and pancreatic cancer is not exactly the same as others. After careful observation and examination, swelling and pain of hepatoma and pancreatic cancer are resulted from several causes. First, due to the stronger nerve responses in the local tissues of these cancers, such as liver ligament, connective tissue, the constrictor, and hepatopancreticae, tiny stimulations could induce contractions of these local tissues and then result in a poor transmission. As a consequence, the severity and frequency of swelling and pain are increased. For this reason, medication with the function of relaxing, smoothing and swaying the nerve is needed. Secondly, most of liver and pancreas mass are occupied by hepatic sinus and pancreas follicles, inside which fluid continuously flow through. A higher temperature of these vessels will be prone to induce inflammatory pathology of vessel walls. Once such condition occurs, the transmission will be hinder to induce swelling and pain. Thus, medication with the function of lowering the temperature and nourishing is needed. Lastly, secretions of liver and pancreas are similarly via mastoids of duodenum. Due to the poor permeability of liver and hypofunction of pancreas, stomach acid secretion is imbalanced and too much mucus, that is phlegm or slayer, is produced in stomach and intestines. In the hepatopancreatic circulation, such mucus will obstacle the circulation to worsen or prolong the swelling and pain. Therefore, it is necessary to include medication with the function of diluting the viscousness.

[0038] In addition to regulation of the surrounding pathology, the pharmacology of medicine combination for treating hepatoma and pancreatic cancer has to focus carefully on the actual variation of six elements in patient's body. Furthermore, medications with functions of relaxing, smoothing and swaying the nerve, lowering the temperature, and diluting the viscousness should be used in coordination. That is, to generate a repulsive environment, which is not suitable for survival of cancer cells, by utilization of medications with functions of relaxing, smoothing and swaying the nerve, lowering the temperature, and diluting the viscousness in the combination. In addition, by altering the cancerous environment to make it back to normal to achieve the objective of cure.

[0039] In this description, conventional and general statements, including spleen augment and correction, regulation and nourishment, circulation stimulation and stasis dispersal, softening and dispersal of bulge, fever alleviation and detoxication, relieving depression and wetness, as well as practical essential pharmacology is also added. Each medication and corresponding pharmacology is described as follow.

[0040] 1. Improvement in the Function of Pancreas and Connections to other Organs:

[0041] Fuling is used in the concentrated extract of this series of cancer treatment to substitute as the effective and modified excipient for the traditional starches of grains and yams and therefore, integrated into each medication. This ingredient, a nutrient supplement, is able to promote the pancreas function and immunity, stabilize the nerve system, regulate rhythm of the heart, enhance water metabolism in organisms, facilitate urination, enhance the immunity of mice of normal or with tumors, and augment the phagocytosis of macrophages. It also has positive effect on various cancers, including nasopharyngeal cancer, gastric cancer, and cervical cancer.

[0042] Baizhu is able to enhance the pancreas function, augment the physical strength and immunity, regulate the connection of pancreas with other organs, promote the water metabolism of organisms and tissues, and facilitate urination, as well as prevent gastric ulcers and intestine cramps, care for the liver and gallbladder, enhance the phagocytosis of reticular endothelium and macrophages, and resist the oxidization. As indicated in Chinese medicine of Shang-Shi (1988) by Jia-Tsai Sun et al., Baizhu can reduce both of proliferation of cancer cells and tumor invasion.

[0043] Danggui can supplement necessary nutrients and inorganic elements, harmonize the connection of pancreas with other organs, enhance the hematopoiesis and circulation, eliminate the thrombi in vessels and prevent thrombosis, as well as promote the conversion of lymphocytes with an auxiliary anti-tumor effect.

[0044] 2. Elimination of the Barriers in Permeability of the Portal Vein, Liver and Pancreas to Decrease the Pressure of the Portal Vein:

[0045] Hanxincao is able to lower the higher temperature in liver and pancreas, promote blood circulation, eliminate the thrombi, bacteria, cancer cells in the portal vein, as well as reduce the pressure of the portal vein, prevent the regression in side circulation and stop the bleeding.

[0046] Huotanmucao is able to improve the water metabolism, lower the blood temperature and detoxification, as well as alleviate the tightness of vessels or tendon ligament, resist the infection of bacteria or hepatitis B virus, and lower the blood pressure. It can also improve the microcirculation of liver and pancreas to promote the permeability.

[0047] Ainaxiang is able to eliminate the pathogenic causes of abnormality in circulation or abnormal pressure in blood capillaries (relieve rheumatic pain), promote the water metabolism of local tissues or organs (amend the wetness), maintain the suitable intra-abdominal temperature, stop diarrhea, smooth the circulation (blood stream) and eliminate the toxin inside the body (detoxication), as well as eliminate those inappropriate or hazardous gas in lymphatic or blood vessels. As indicated by Fuijimoto et al., the growth of Yoshida sarcoma could be inhibited by 5-10 kg/ml of blumealactone A, B, C extracted from the leaves of Ainaxiang.

[0048] Shuodiao is able to eliminate the causes for abnormal pressure in vessels and capillaries (relieve rheumatic pain), abolish the hindrance of water metabolism in local tissues or organs (expel the wetness), relieve the pain, help urination, promote circulation to disperse thrombi, and preserve liver function, as well as preserve the normal blood pressure and water metabolism around the tumor tissues to alleviate sharp pain caused by cancer.

[0049] 3. Enhancement in the Defensive Function, Lymphatic Circulation, and Immunity:

[0050] Malan, with a stable capability of detoxication, is able to enhance defensive function, lower the higher temperature around cancer tissues, and increase the nutrient elements in the blood to eliminate symptoms including inflammation, hyperemia and swelling. An ingredient, indirubin, is capable of resisting the tumor formation and enhancing the phagocytosis of monocytes of mice and also has significant effect on the abnormality of cancer environment.

[0051] Ludou, a nutrient, is able to supplement consumed energy, lower the high temperature caused by drastic ingredients (supplementing pancreas and clarify illusory heat), and eliminate toxic materials inside body, especially in liver and kidney to promote urination (detoxication and urination). It can also reduce cholesterol, resist atherosclerosis, and significantly alleviate the damage to kidney and liver. As indicated by Han-Yuan Chen et al in the Academic Journal of First Medical University in 1989, the diet containing Ludou powder can reduce the number and mass of lung cancer and hepatoma induced by morphine and nitrous acid. The pharmacological effect of Ludouhuang, a preparation of Ludou and less nutritious, is even stronger, especially in the aspects of detoxication and reduction in inflammation, and has positive influence on the cancer surrounding.

[0052] Canger is able to eliminate the causes for abnormal pressure of vessels and capillaries, relieve the higher temperature inside body and skin (dispersal of wind and heat), remove toxins in defensive system and tissues, and kill germs and bugs (detoxication and eradication of bacteria), as well as eliminate the obstacles in lymphatic circulation, and treat leprosy and early stage of blood fluke infection.

[0053] Daqinggen is capable of relieving the body heat and high temperature on skin caused by lymphatic alteration and reducing the high temperature of blood, liver and pancreas to promote lymphatic permeability and normal circulation.

[0054] Banbianlian can penetrate lymphatic microcirculation in deep area of organs to activate the defensive function and neutralize the toxins and promote urination, secretion of bile and resistance to venom, as well as treat liver cirrhosis, ascites and various cancers.

[0055] Xingren, used as external medicine of skin cancer on knees in ancient time, can go deep into acidic environment of cancer to alter the condition. As indicated in Shansi Journal of Medicine by Su-Lian Zhao, muscular injection of amygdalin significantly promoted the mitosis and proliferation of spleen T lymphocytes in mice.

[0056] Nuzhenzi is able to supplement mild nutrients and trace inorganic elements to liver and kidney to activate immunity and amend the nature and circulation of lymphatic system.

[0057] 4. Pathological Amendments Specific for Hepatoma and Pancreatic Cancer:

[0058] Qianhu can regulate body temperature, guide the inappropriate air in the tissue (leading the air), dilute and expel viscous liquid (reducing phlegm and making expectoration easy), promote metabolisms in digestive and respiratory system (metabolism), as well as to aid other medications in the metabolisms in lung, stomach, liver and pancreas to renovate the air and nature.

[0059] Jiatonghao can eliminate drastic elements in blood, lower the higher temperature of liver, gallbladder and pleura, and smooth the local lymphatic circulation to rapidly alleviate local inflammation and pain of cancer tissues.

[0060] Yinchenhao is able to eliminate retained water and lower the higher temperature and also able to lead hazardous materials and elements out of liver and gallbladder to promote the smooth flow of intrahepatic bile duct. It was indicated by Jen-Sha Lo in Academic Journal of Fu-Jian Medical College that decoction of Yinchenhao could resist tumor growth and inhibit mutations. In Communication of He-Han Chinese Medicine Association, Chiang-Shiu et al., have shown that Yinchenhao can direct hinder the proliferation of cancer cells.

[0061] Yujin can relax the hepatic ligament to reduce pressure and make the secretion of pancreas and bile smooth. In addition, Yujin can protect liver and myocardium against damage and enhance the immunity.

[0062] Zhishi can stimulate smooth muscles of stomach and intestine to increase the electric frequency and therefore, promote the excretions of abnormal materials. It can also dilute those viscous liquid in the hepatopancreatic circulation for the smooth flow in intrahepatic bile duct.

[0063] Banxia is able to anesthetize the nerve for vomit to alleviate the hypersensitivity of upper digestive tracts (stop vomiting and backflow), reduce the gastric acid secretion to diminish abnormal acidity in the cancer environment, prevent overproduction of viscous liquid to eliminate local hindrance in circulation. It also exhibited significant inhibition on the growth of hepatoma, sarcoma, and cervical cancer in animal studies. Pharmacological Data of Medication Name of Chinese Fuling The formal name Poria cocos (schw.) WOLF. herbal medicine Foundation Page 1596 of Dictionary of Chinese Medicine and page 554 of Chinese material medica Book 1 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Fuling is produced in Hubei and Anhui and matured after being harvest season, and cultured for 8 to 10 months. The plant is stripped to check and should portion be harvested if the color of surface is brown. It should be dug out on a shiny day and, after removing the dirt and sand, covered with straw to make it sweat (water). After the surface wrinkling, the surface skin is stripped off and Fuling is dried. Procedures for 1. Those heavy, hard, brown-skinned, fine striped, no crack, white preparation and and smooth at the cross-section, and strongly sticky Fuling are extraction selected, stripped to remove the skin, immersed to be soften, dissected to be thin sections and dried. 2. Fuling of 50 kg is grounded, screened through a sieve of 120 and stored as powder. Active ingredients Containing β-Pachyman, about 93% of dried weight, Pachymicacid, 3β-Hydroxylanosta-7.9(11), 24-trien-21-oil acid and additionally, gelatin, chitosans, fatty acid, sitosterol, lecithin, glucose, adenosine, histidine, choline, β-Pachymanase, lipase, proteinases, as well as 0.23% of inorganic Ash and elements including Fe, Ca, Mg, K, Na, Ce, and P. Original Originally, it is used to augment the nutrient, promote the pancreas pharmacological function and immunity, stabilize the nerve system, regulate rhythm of action the heart, enhance water metabolism in organisms, and facilitate urination. Currently, it is used to enhance the immunity of mice of normal or with tumors, augment the phagocytosis of macrophages, and positively effect on various cancers, including nasopharyngeal cancer, gastric cancer, and cervical cancer. Pharmacological Used to augment the nutrient and promote the pancreas function, application and immunity and water metabolism. In this invention, Fuling is used as an purpose excipient. All concentrated extracts, except those were not extracted and dried, are mixed with pure Fuling powder instead of the conventional edible starches of grains and yams. Name of Chinese Baizhu The formal name AtractyLodes herbal medicine Macrocephala Koidz Foundation Page 670 of Dictionary of Chinese Medicine and page 715 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Baizhu is produced in Zhejiang. After the dryness of the portion harvest season, and aboveground in November, roots were dug out and clean to portion remove any dirt and stems and then baked at 100□. Till the surface is hot, temperature was reduced to 65□for 4-6 hours with one inversion. Those fibrous roots were removed while half dried and then baked again till 80% dryness. After 5-6 days of storage for softening the surface skin, they were baked till being thoroughly dry. Procedures for 1. Baizhu of 4 kg is washed clean, sectioned, immersed in preparation and water for 3 hours and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, Fuling of 1 kg is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 100 and stored as powder. Active ingredients Tens of various volatile oil, including atractylone, atractylenolide, 14-acetyl-12-Senecioyl-2E, 8Z, 10E atractylentriol, scopolamine, fructose, inulin, Mannan AM-3, which is functional in immunity, and tyrosine. Original Baizhu is able to enhance the pancreas function, augment the pharmacological physical strength and immunity, regulate the connection of action pancreas with other organs, promote the water metabolism of organisms and tissues, and facilitate urination. It modern pharmacological action include prevent gastric ulcers and intestine cramps, care for the liver and gallbladder, enhance the phagocytosis of reticular endothelium and macrophages, and resist the oxidization. As indicated in Chinese medicine of Shang-Shi (1988) by Jia-Tsai Sun et al., Baizhu can reduce both of proliferation of cancer cells and tumor invasion. Pharmacological To improve the pancreas function and immunity, regulate the application and connection of pancreas with other organs, care for the liver and purpose gallbladder, and significantly alter the cancer environment. Name of Chinese Danggui The formal name Anqelica Sinensis herbal medicine (Oliv) Diels Foundation Page 876 of Dictionary of Chinese Medicine and page 893 of Chinese material medica Book 5 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Danggui is produced in Min Chian of Gansu. At late October, harvest season, and roots are cleaned by removing any dirt and stems. After portion semi-dried by air ventilation, they are bound as a bundle and smoked to dry. Procedures for 1. Danggui of 5 kg is washed clean, sectioned into 3 or 4 preparation and stripes, immersed in water for 3 hours and then decocted in extraction two parts. 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, Fuling powder of 1 kg is mixed into. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 100 and stored as powder. Active ingredients 12 types of volatile oils, including carvacrol, 11 types of aldehydes, inculding verbenone, 26 neutral oils, including liqustilide, 17 placid ingredients including anqelicide and 18 amino acids, including lysine, as well as 9 phospholipids, including lysophos phatidylcholine and 23 inorganic elements and polysaccharide. Original To enhance the hematopoiesis and circulation, eliminate the pharmacological thrombi in vessels and prevent thrombosis. action Modern Pharmacology: To positively affect the circulation and hemopoietic system and promote the conversion of lymphocytes with an auxiliary anti-tumor effect. Pharmacological To supplement necessary nutrients and inorganic elements, application and promote the circulation and conversion of lymphocytes, purpose strengthen the cardio function and eliminate the thrombi in blood Name of Chinese Hanxincao The formal name Scutellaria indica L. herbal medicine Foundation Page 2303 of Dictionary of Chinese Medicine and page 214 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Hanxincao is produced in Fujian and Taiwan. The whole weed harvest season, and is harvested in spring and summer, cleaned and sun-dried. portion Procedures for 1. 5 kg of the whole weed is washed clean and immersed in preparation and water for 3 hours and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, Fuling powder of 1 kg is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Including various types of flavone, including scutellarein, and 5 types of Sophoradin, as well as phenolic compounds, amino acids, organic acid and 2, 3, 4, 5, 2′, 4′, 5′, 6′-Octamethoxychalcone. Original Hanxincao is able to lower the higher temperature of organisms, pharmacological promote blood circulation, alleviate the inflammation and action swelling of infected connective tissues, and augment the defense and detoxication, as well kill the pain, reduce inflammation and stop the bleeding Pharmacological Hanxincao is able to lower the higher temperature in liver and application and pancreas, promote blood circulation, eliminate the thrombi, purpose bacteria, cancer cells in the portal vein, as well as reduce the pressure of the portal vein, prevent the regression in side circulation and stop the bleeding. Name of Chinese Huotanmucao The formal name Polyqonum herbal medicine chinenSeL Foundation Page 500 of Dictionary of Chinese Medicine and page 648 of Chinese material medica Book 2 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Huotanmucao is produced in Fujian and Taiwan. The portion of harvest season, and plant above ground is harvested between summer and autumn, portion cleaned, sectioned and sun-dried. Procedures for 1. 1 kg of dried Huotanmucao is desiccated and ground and preparation and additional 5 kg is immersed in water for 3 hours and then extraction decocted in two parts. 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, the original powder of 1 kg is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The leave of Huotanmucao contain β-sitosterol, kaempferal, quercetin, ellaqicacid, qallicacid, 3-O-methylellaqic acid, kaempferol-7-qlucoside and kaempferol-3-O-qlucuronide Original Huotanmucao is able to improve the water metabolism, lower pharmacological the blood temperature and detoxification, as well as alleviate the action tightness of vessels or tendon ligament. Modern pharmacology: to resist the bacteria or hepatitis B virus infection, and lower the blood pressure. Pharmacological To improve the microcirculation of liver and pancreas to application and promote the permeability, lower the pressure of portal vein and purpose regulate the hepatic and pancreatic functions. Name of Chinese Ainaxiang The formal name Blumea balsainifera herbal medicine (L) DC. Foundation Page 562 of Dictionary of Chinese Medicine and page 738 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Huotanmucao is produced in Taiwan. The portion of plant above harvest season, and ground is harvested in autumn, cleaned, sectioned and portion sun-dried. Procedures for 1. 8 kg of dried sections is immersed in water for 12 hours preparation and and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, Fuling powder of 1 kg is mixed into. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The leave of Ainaxiang contain (2R, 3R)-dihydroquerce-tin-4′-methylether, blumealactone, A, B, C, and blumeatin, as well as borneol Original Ainaxiang is able to eliminate the pathogenic causes of pharmacological abnormality in circulation or abnormal pressure in blood action capillaries, promote the water metabolism of local tissues or organs, maintain the suitable intra-abdominal temperature, stop diarrhea, smooth the circulation and eliminate the toxin inside the body. As indicated by Fuijimoto et al., the growth of Yoshida sarcoma could be inhibited by 5-10 kg/ml of blumealactone A, B, C extracted from the leaves of Ainaxiang. Pharmacological In conjunction with other medications, it can eliminate application and inappropriate or hazardous gas from lymphatic or blood vessels purpose by its function of urging the blood flow. Name of Chinese Shuodiao The formal name Sambucus javanica herbal medicine Reinuw Foundation Page 2455 of Dictionary of Chinese Medicine and page 541 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Shuodiao is produced in South China along the coast and harvest season, and Taiwan. After harvested in summer and autumn, roots and stems portion are sectioned and used while fresh. Young branches and leaves are finely chopped and sun-dried followed by grounding, screening through a sieve of 120 and storing as powder. Procedures for 1. 20 kg of fresh roots and stems are immersed in 2 liters of preparation and 18□ rice wine and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrate remaining, 1 kg of leave powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The whole weed contains flavone, phenolic compounds, tannin, saccharide, and chlorogenic acid. In addition, the dried leaves contain β-sitosterol, stigmasterol, α-amyrin, palmitate, ursolic acid and massive potassium nitrate Original Shuodiao is able to eliminate the causes for abnormal pressure pharmacological in vessels and capillaries (relieve rheumatic pain), abolish the action hindrance of water metabolism in local tissues or organs (expel the wetness), promote circulation to disperse thrombi, relieve the pain, help urination In a clinical report, it was indicated that injection of 100% Shuodiao solution is effective in treatint acute bacterial diarrhea and acute tonsillitis, as well as pneumonia. Decoction and power of Shuodiao is effective against acute and chronic hepatitis. Pharmacological To promote circulation to disperse thrombi and preserve the application and normal blood pressure and water metabolism around the tumor purpose tissues to alleviate sharp pain caused by cancer. Name of Chinese Malan The formal name Baphicacanthus herbal medicine cusia (Nees) Bremek Foundation Page 1270 of Dictionary of Chinese Medicine and page 450 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Malan is produced in Fujian and Taiwan. After harvested in harvest season, and autumn, the whole plant is washed clean and separated as roots, portion stems and leaves. Leaves and young branches are sun-dried, grounded and screened through a sieve of 100 and stored as powder. Roots and stems are sectioned and sun-dried. Procedures for 1. 8 kg of roots and stems are immersed in water for 8 hours preparation and and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 4 liters of concentrates remaining. After cooling down, 1 kg of leave powder is mixed into till sticky. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Leaves of Malan contain indicant, indirubin, indigo, and tryptantrin while the whole plant contains lupeol, betumin, lupenone, 4(3H)-quinazolinone and 2,4(1H, 3H)-quinazolinedione. Roots contain additionally chrysophand and β-sitosterol. Original Malan is able to lower abnormal temperature of organisms, pharmacological increase the nutrient elements in the blood, neutralize the toxins, action alleviate inflammation and hyperemia and stop bleeding. In modern pharmacology, one ingredient of Malan, indirubin, is capable of resisting the tumor formation and enhancing the phagocytosis of monocytes of mice. It has been proven to be clinically effective in treating infections of Spirochaete, Influenza Meningitidis, Mumps and Rosella. Pharmacological To significant effect on the abnormality of cancer environment application and by functions of alleviating inflammation and hyperemia and purpose detoxication. Name of Chinese Ludou The formal name Viqna radiate (L.)R herbal medicine Foundation Page 2271 of Dictionary of Chinese Medicine and page 694 of Chinese material medica Book 4 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Ludou is produced in Taiwan. During mid August, seeds are harvest season, and mature, harvested and screened to remove any undesirable portion materials and then sun-dried. Procedures for 1. 10 kg of seeds are washed clean and dried. A hole of 1 cm preparation and is drilled at the middle of fresh bamboo tubes with two end extraction joints being kept and Ludou seeds are put in with 1/3 space left. The hole is then closed by bamboo plug, paraffin, and tape wrapping for air proof. 2. Immersion in urines of health person for at least 49 days. 3. Immersion with turning in a bucket of flowing spring. The inlet direction of spring is from bottom and outlet from the top for at least 49 days. 4. In a water reservoir with a presumed volume of 40 tons, spring water inlet from top. Those bamboo tubes with Ludou are immersed at the bottom of reservoir for at least 49 days. 5. After retrieving, bamboo tubes are placed on a clean ground and turned one or twice a day for sun, dew, wind, and rain. After 49 days, the bamboo tubes are open, sun-dried, ground, and screened through a sieve of 100 and stored as powder. Active ingredients Ludou contains carotene, riboflavine, blobulin, fructose and phophoslipids, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidylserine, and phosphatidicacid. Original Ludou, a nutrient, is able to supplement consumed energy, lower pharmacological the high temperature caused by drastic ingredients action (supplementing pancreas and clarify illusory heat), and eliminate toxic materials inside body, especially in liver and kidney to promote urination (detoxication and urination). In modern pharmacology, it can also reduce cholesterol, resist atherosclerosis, inhibit the increase of BUN, promote the excretion of creatine, increase the urination amount to promote the excretion of urine phosphate and significantly alleviate the damage to kidney and liver. As indicated by Han-Yuan Chen et al in the Academic Journal of First Medical University in 1989, the diet containing Ludou powder can reduce the number and mass of lung cancer and hepatoma induced by morphine and nitrous acid. Pharmacological To eliminate toxic materials inside body, especially in liver, application and pancreas and kidney and lower the high temperature around purpose tumors. The pharmacological effect of Ludouhuang, a Ludou extract, is even stronger, especially in the aspects of anti-infection and reduction in inflammation in cancer surrounding area. Name of Chinese Canger The formal name Xanthium sibiricum herbal medicine patrex widd. Foundation Page 1069 of Dictionary of Chinese Medicine and page 1010 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Canger is produced in Fujian and Taiwan. After harvested in harvest season, and spring, the whole plant is washed clean, sectioned and portion sun-dried. Procedures for 1. 6 kg of newly dried Canger are firmly pressed into a pot preparation and with adding of 2 liters of 18° C. rice wine. After heat extraction steaming for softening, water is added into and decoction is performed twice. 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The whole plant contains strumaroside, xanthinin, and xanthumin, as well as derivatives of Sophoradin, soluble nucleoside, glucose, fructose, amino acid, Tartaric Acid, succinic acid, fumaric acid, Malic Acid, potassium nitrate, calcium sulfate, and iodine. Original Canger is able to eliminate the causes for abnormal pressure of pharmacological vessels and capillaries, relieve the higher temperature inside action body and skin (dispersal of wind and heat), remove toxins in defensive system and tissues, and kill germs and bugs (detoxication and eradication of bacteria). In clinical reports, it has been reported to treat leprosy and chronic rhinitis, functional metrorrhagia and early stage of blood fluke infection. Pharmacological To permeate lymphatic tissues for removing toxins in defensive application and and endoreticular systems. purpose Name of Chinese Daqinggen The formal name Clerodendron herbal medicine Cyrtophyllum Turez Foundation Page 129 of Dictionary of Chinese Medicine and page 567 of Chinese material medica Book 6 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Daqinggen is produced in Jiangsi. Roots and stems are dug out harvest season, and in summer, washed, sectioned and sun-dried. portion Procedures for 1. 8 kg of Daqinggen sections are immersed in water for 12 preparation and hours, heated and decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The stems contain crytophyllone A and B, teuvincenone F, sugiol, triedelin, clerodolone, clerosterol, and stigrna-5, 22, 25-trien-3B01. Original Daqinggen is capable of relieving the body heat and high pharmacological temperature on skin caused by lymphatic alteration and reducing action the high temperature of blood, as well as helping in detoxication of lymphatic tissues. Pharmacological To lower the higher temperature in blood and hepatic vessels application and and promote lymphatic permeability and normal circulation. purpose Name of Chinese Banbianlian The formal name Lobelia Chinensis Lour herbal medicine Foundation Page 754 of Dictionary of Chinese Medicine and page 613 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Banbianlian is produced in Anhui, Fujian and Taiwan. After harvest season, and harvested in spring and autumn, the whole plant is washed clean portion and sun-dried. Procedures for 1. 4 kg of Banbianlian are immersed in water for 3 hours and preparation and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Banbianlian contains alkaloids, mainly L-lobeline, lobelanine, lobelanidlne, isolobelanine, flavonoids, saponin, amino acid, polysaccharides, inulin, p-hydroxyacid, and succinic acid. The root and stem of Banbianlian contains lobelinin. Original Banbianlian can lower the higher temperature in tissue, activate pharmacological defensive tissues, promote detoxication (elimination of heat and action detoxication), enhance water metabolism, eliminate ascites and swelling of shin (helpful in elimination of water and swelling), penetrate lymphatic microcirculation of internal and neutralize the toxins. In modem pharmacology, it can promote urination, secretion of bile and resistance to venom, as well as treat liver cirrhosis, ascites and various cancers. Pharmacological To penetrate into the lymphatic microcirculation of deep portion application and of tissue and activate defensive organs to promote detoxication. purpose Name of Chinese Xingren The formal name Armeniaca Vulgaris herbal medicine Lam Foundation Page 1100 of Dictionary of Chinese Medicine and page 93 of Chinese material medica Book 4 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Xingren is produced in Northern China and east of Inner harvest season, and Mongolia. During the maturation season of June and July, the portion fruits are picked. After removing the flesh and washing and being dries, the kernel is retrieved by cracking the nutlet and sun-dried and protected from eaten by bugs. Procedures for 1. 5 kg of Xingren are washed, cracked and immersed in preparation and water for 3 hours and then decocted in two parts. After extraction heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 2. Desiccation at 60° C. 3. The product is grounded and screened through a sieve of 80 and stored as powder. Active ingredients Xingren contains amygdalin of around 4%, prunasin, fatty oil of about 50%, which is consist of 8 fatty acids, including 27% of linoleic acid, 67% of oleic acid and 5.2% of palmitic acid, as well as chlorogenic acid and neochlorogenic acid. Apart from these, KR-A and KR-B with functions of anti-inflammation and pain killing, and volatile ingredients related to the scent of Xingren are also contained Original Xingren is able to alleviate the hypersensitivity to the trachea pharmacological and bronchus in lung (stop coughing and smooth panting), action lubricate the intestines and smooth excretion. It was used as external medicine of skin cancer on knees in ancient time. As indicated in Shansi Journal of Medicine by Su-Lian Zhao, muscular injection of amygdalin significantly promoted the mitosis and proliferation of spleen T lymphocytes in mice. Pharmacological To go deep into the acidic environment of cancer to collaborate application and with other medications in altering the condition for treating purpose cancers. Name of Chinese Nuzhenzi The formal name Ligustrum Lucidum Ait herbal medicine Foundation Page 237 of Dictionary of Chinese Medicine and page 183 of Chinese material medica Book 6 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Nuzhenzi is produced in Zhejiang and Jiangsu. Seeds are harvest season, and harvested in December. After removing stems, leaves and portion others, seeds are placed in hot water to scald and then sun-dried. Procedures for 1. 8 kg of Nuzhenzi are washed and immersed in water for 3 preparation and hours and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Nuzhenzi contains oleanolic acid, ursolic acid, various nucleosides, polysaccharides, and 7 types of phospholipids of a total 0.39%, as well as 11 elements, including K, Ca, Mg, Mg, Na, Zn, Fe, Mn, Cu, Ni, Cr, and Ag. Ligustrin, one ingredient, is able to activate the immunity. Original Nuzhenzi is able to supplement mild nutrients and trace pharmacological inorganic elements to liver and kidney for augmenting hepatic action and pancreatic functions, reduce the abnormal high temperature and non-specific heat caused by retentions of drastic elements in liver and kidney, alleviate the permeability of lymphatic system, reduce cholesterol in blood and reduce white blood cells. Pharmacological To supplement trace inorganic and mild nutrients elements, application and amend cytokines and lymphatic circulation to activate the purpose immunity. Name of Chinese Qianhu The formal name Peucedanum herbal medicine Praeruptorum Dunn Foundation Page 1723 of Dictionary of Chinese Medicine and page 1008 of Chinese material medica Book 5 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Qianhu is produced in Sichuan and Jiangsi. Roots are dug out in harvest season, and winter and sun-dried after removal of dirt. portion Procedures for 1. 6 kg of Qianhu are washed, and sectioned. 1 kg of these are preparation and grounded and the other 5 kg are immersed in water for 8 extraction hours and then decocted in two parts. 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of original Qianhu powder is mixed into. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 100 and stored as powder. Active ingredients Qianhu contains various coumarins, incuding praeruptorin A, coumaringlycosides, such as marmesinin, and D-mannitol, β-sitosterol, galactitol, daucosterol, and pd-saponin V. Original Qianhu can regulate body temperature, guide the inappropriate pharmacological air in the tissue (leading the air), dilute and expel viscous liquid action (reducing phlegm and making expectoration easy), alleviate the nerviness in lung and upper digestive tracts, and promote metabolisms in digestive and respiratory system (metabolism). Pharmacological To aid other medications in the respiratory, circulatory, and application and digestive systems to renovate the air and nature, especially in purpose the metabolism in lung, stomach and pancreas. Name of Chinese Jiatonghao The formal name Crassocephalum, herbal medicine crepidioides (Benth) Foundation Page 2183 of Dictionary of Chinese Medicine and page 792 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Jiatonghao is produced in Fujian and Taiwan. The whole plant is harvest season, and harvested while being in buds in summer, washed and spread in portion ventilated place for 1 to 2 hours followed by chopping and storage. It is best to concentrate and extract right away. The efficiency sharply decreased after being ground or stored. Procedures for 1. 8 kg of dried Jiatonghao are immersed in 1 liter of 18° C. preparation and rice wine for 3 hours and then decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Not clear Original Jiatonghao can eliminate drastic elements in blood, lower the pharmacological higher temperature, enhance water metabolism of organisms, action promote urination and excretion, and reduce inflammation. It was originally a folk prescription, but significantly effective in treating pain and high fever caused by pleurisy and pleuritic infection. Pharmacological To eliminate drastic elements in blood, lower the higher application and temperature, especially in pleura, enhance water metabolism of purpose organisms, and assist other medications in quickly relieving the local swelling and pain of hepatoma and pancreatic cancer. Name of Chinese Yinchenhao The formal name Artemisia Capillaris herbal medicine Thunb Foundation Page 1588 of Dictionary of Chinese Medicine and page 687 of Chinese material medica Book 7 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Yinchenhao is produced in Fujian and Taiwan. Young branches harvest season, and are harvested in late spring and semi-dried in the shade followed portion by sun-dried. Procedures for 1. 1 kg of Yinchenhao is grounded and another 5 kg of preparation and Yinchenhao are immersed in water for 3 hours and then extraction decocted in two parts. 2. After slow heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of original Yinchenhao powder is mixed into. 3. Desiccation at 45° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients The portion above ground contains volatile oil such as α-β-alkene and limonene, various styrenes and di-biethyl compounds such as capillone, various phenolic compounds such as phenol, and 15 types of fatty acids such as palmitica acid. The portion above ground contains 4 phenoxyketones such as capillarisin, as well as flavone such as cirsilineol, which is beneficial for gallbladder, and capillartemisin A and B. Original Yinchenhao is able to eliminate retained water and lower the pharmacological higher temperature with functions of alleviating heat, action eliminating inflammation and being beneficial for gallbladder. In modern pharmacology, it can conserve the functions of liver and pancreas, alleviate heat, eliminate inflammation, kill pain and resist microbiological infections. As indicated by Jen-Sha Lo in Academic Journal of Fu-Jian Medical College, decoction of Yinchenhao could resist tumor growth and inhibit mutations. In Communication of He-Han Chinese Medicine Association, Chiang-Shiu et al. have shown that Yinchenhao can direct hinder the proliferation of cancer cells. Pharmacological To eliminate retained water from liver and gallbladder and lower application and the higher temperature and also able to lead hazardous bacteria purpose and cancer cells out to promote the normalization of intrahepatic environment. Name of Chinese Yujin The formal name Curcuma chuanyujin herbal medicine C. K. Hsiehet H. Zhang Foundation Page 1316 of Dictionary of Chinese Medicine and page 637 of Chinese material medica Book 8 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Yujin is produced in Sichuan. In late December, after removing harvest season, and withered stems and leaves, the underground portion is dug out portion and cleaned to remove dirt. After being steamed for 15 minutes, it is baked to dry and fibrous roots removed. Procedures for 1. 6 kg of Yujin are sectioned. 1 kg of Yujin is grounded into preparation and fine powder and another 5 kg of Yujin are immersed in extraction water for 8 hours and then decocted in two parts. 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of original Yujin powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Curcumin, demethoxycurcumin, and bidemethoxycrucumin are contained. Original Yujin can promote blood and lymphatic circulation, relax the pharmacological tightness of ligaments in liver, pancreas, and stomach, kill pain action and promote the bile secretion. In modern pharmacology, Yujin can protect liver and myocardium against damage and enhance the immunity. Pharmacological To loosen the liver ligament and promote the circulation of liver application and and pancreas to help bile secretion. purpose Name of Chinese Zhishi The formal name Citrus aurantium L herbal medicine Foundation Page 1508 of Dictionary of Chinese Medicine and page 874 of Chinese material medica Book 4 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Zhishi is produced in Sichuan, Hunan, and Jiangsi. Youthful harvest season, and fruits are picked in May and June, cross-sectioned and portion sun-dried. Procedures for 1. 6 kg of Zhishi are immersed in water for 8 hours and then preparation and decocted in two parts. extraction 2. After heating to evaporate the moisture till 3 liters of concentrates remaining, 1 kg of Fuling powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 100 and stored as powder. Active ingredients Hesperidin, neohesperidin, naringin, synephrine, and N-methyltyramine are contained. Seeds contain limonoids, as well as 19-hydroxydeacetylnomilinic acid-17-B-D-glucoside. Original Zhishi can stimulate digestive tracts to eliminate abnormal pharmacological materials and their aggregation, and dilute viscous liquid in the action circulation (reduce phlegm and expel wetness). Pharmacological Zhishi can stimulate smooth muscles of stomach and intestine to application and increase the electric frequency and therefore, promote the purpose excretions of abnormal materials. It can also dilute viscous liquid in the hepatopancreatic circulation for the smooth flow in intrahepatic bile duct. Name of Chinese Banxia The formal name Pinellia ternate (Thunb) herbal medicine Breit Foundation Page 775 of Dictionary of Chinese Medicine and page 513 of Chinese material medica Book 8 (published by Shanghai Scientific and Technical Publishing Company) The place of origin, Banxia is produced in Hubei, Henan and Shandong. Stem tubers harvest season, and are dug out in October and November. After removing dirt and portion being classified by size, stem tubers are skinned by pounding under flowing water, washed clean and sun-dried. Immersions in lime and licorice root are performed in sequential till numb taste and even yellow coloring of sections. Procedures for 1. 1 kg of Banxia, which has been prepared and sectioned, is preparation and sprayed with 10 cc of water to mix. Another 4 kg of Banxia extraction is immersed in water for 8 hours and then decocted in two parts. 2. After heating to evaporate the moisture till 2.5 liters of concentrates remaining, original powder is mixed into. 3. Desiccation at 60° C. 4. The product is grounded and screened through a sieve of 120 and stored as powder. Active ingredients Over 60 ingredients, such as volatile oil and 3-acetoamino-5-methylisooxazole are contained, as well as ephedrine, choline, amino acid, and inorganic elements such as Ca, K, Na, Fe, Al, Mg, Mn, T, and P. In addition, it contains polysaccharide amylose, banxia protein, and pancreatin. Original Banxia is able to anesthetize the nerve for vomit to alleviate the pharmacological nerviness of upper digestive tracts (stop vomiting and action backflow), dilute and prevent the formation of viscous materials in intestines, and reduce the gastric acid secretion. In modern pharmacology, it can reduce gastric acid secretion to reduce the acidity of free and total acids, inhibit the activity of pepsin for protection against acute damage and promote the repair of mucous membrane. In the Pharmacology of Chinese Medicine, Yi-Kui Lee indicated that water extract of Banxia exhibited significant inhibition on the growth of hepatoma, sarcoma, and cervical cancer in animal studies. Pharmacological To reduce the acidity of free and total acids, reduce the viscosity application and of circulation to lead to the easy access of cancer medications purpose for altering the environment.

[0064] Preparations of Medication

[0065] Abovementioned powder medicines, after concentration and extraction (please refer to Pharmacological Data of Medication for procedures), are mixed at indicated ratios in a blender. After adding an appropriate amount of water, the slightly moistened powders are processed as tablets of 0.5 mg/tablet by a tablet presser, desiccated at 45° C. and stored in sealed glass bottles. Stored at a dry and cool place for further use.

[0066] Usage

[0067] Regardless of stages, primary or metastatic, or undergone therapy of dissection, thrombosis, chemotherapy, or radiation, any patients with hepatoma or pancreatic cancer could use. At 90 minutes after every meal, 8 tables are swallowed with water. The dosage should be decreased or halved for children.

[0068] Matters Needing Attention

[0069] Tablets could be only taken after at least 10 days of chemotherapy or radiation therapy, if patients have undergone. While taking these tablets, thrombosis, chemotherapy and radiation therapy are prohibited. Other medications or health foods are also contradicted to prevent interference. Torrid foodstuffs, such as onion, garlic, chives, alcohol, Chinesered pepper, thick sauce, and spices, including prickly ash, star anise, cinnamon, clove and fennel, are prohibited to use. The living place should not use toxic materials such mosquito coil incense or spray or germicide. Intensive exercise is not recommended and all social activities or engagements should be halted.

[0070] The Clinical Trial

[0071] The Aim and Description of this Trial:

[0072] By complying with certain regulations, one medication combination for treating hepatoma and pancreas was continuous given to evaluate the actual efficiency and statistically analyzed to conclude.

[0073] For consideration of subjects' lives and continuity of trials, alternative medications was administrated in case of non-cancer diseases and accidental symptoms and this trial medicine was continued without directly affecting the trial results.

[0074] The Strict Standards of Trial Subjects:

[0075] The Expelling of Trial Subjects:

[0076] Any patients, who have not been diagnosed by well-equipped hospitals, were expelled. Patients with cancers other than hepatoma or pancreatic cancer or with insignificant main symptoms, which may mislead the evaluation, were expelled. Those patients had undergone less than 3 treatment courses (12 days for each course) were also expelled due to a too short continuity, which may be misleading.

[0077] The Duration of Trial:

[0078] This trial has been carried out from March 1997 to December 2001. Regardless of tumor stages, types or efficiency, any patient complies with the abovementioned standard was recruited into this trial.

[0079] The Maintenance of Data:

[0080] All related information, in addition to be serially kept in “the practical execution of clinical trial” enclosed in this proposal, is maintained in the database of original hospitals which make the diagnosis and this execution unit.

[0081] Standards for Evaluation:

[0082] Significant efficiency: the main symptoms or pain of cancer disappear, or dispersion of partial tumor mass is seen by scientific examination such as scan and such dispersion continues till the end of trial. These are classified as significant efficiency.

[0083] With efficiency: the main symptoms or pain of cancer reduce significantly, or recession of tumor mass is seen by scanning and such recession of tumor continues till the end of trial.

[0084] Inefficiency: the main symptoms or pain of cancer are improved insignificantly, not improved, or continuing deteriorated.

[0085] Unknown: unable to evaluate due to unclear responses of subjects or lose contact. These unknown cases are classified as no efficiency.

[0086] Efficiency and Statistical Analysis:

[0087] A total of 77 cancer patients matched the standards of this trial.

[0088] Efficiency: in this trial, the efficiency rate is 79%, including 25 patients with significant efficiency and 36 patients with efficiency to give a total of 61 patients. Meanwhile, 13 patients with no efficiency and 3 patients were unknown to give a total of 16 patients (21%).

[0089] Gender: 55 male (71%) and 22 female (29%)

[0090] Category of hospitals: 20 patients from the 1^(st) grade hospitals (teaching hospitals, such as National Taiwan University Hospital, National Cheng Kung University Hospital, and Kaoshiung Medical Univeristy Hospital), 54 patients from the 2^(nd) grade hospitals (region hospitals, such as Navy General Hospital, Veterans General Hospitals, Chang Gung Hospital, and Chi Mei Hospital), 3 patients from the 3^(rd) grade hospitals (well-equipped general hospitals), and none from the 4^(th) grade hospitals (general hospitals without adequate equipments).

[0091] Prior to joining the trial: 6 patients (8%) directly enrolled into this trial and 68 patients (88%) join this trial after having inefficient treatments including dissection, thrombosis, chemotherapy, and radiation therapy. Furthermore, 3 patients were uncertain in this aspect.

[0092] Recurrence, spreading and metastasis: after treatment with western medications, the recurrence, spreading and metastasis have occurred in 21 patients (27%) and inefficiency and deterioration have occurred in 41 patients (53%).

[0093] Age: the average age of these 77 patients was 62 years old with the highest being 91 and the lowest being 36.

[0094] Descriptions of Ordinary Subjects in this Trial

[0095] Only 9 cases are concisely stated in this description and the detailed statements of these 9 cases and other 68 cases are enclosed in appendix 1.

[0096] 1. No.2, Mr. Wang, Born in 1932, Male

[0097] After being diagnosed as pancreatic cancer in a hospital of the 2^(nd) grade at March 2001, he was hospitalized and treated at the original hospital with a implantation of a bile catheter. This execution unit was informed on March 15 and he was treated for a total of 3 times with medications for 15 days.

[0098] On April 17, he was transferred to another hospital of the 2^(nd) grade to undergo a surgical dissection of gallbladder, pancreatic-bile duct, a part of pancreas, duodenum (about 2 inches), and stomach (½) since all abovementioned areas have been infiltered by cancer cells. On May 10, he officially came in for seeking treatment. His main symptoms including hindrance in upper digestive tracts and stomach and continuous hiccup after meals, as well as numbness and tightness in right costal area, tiredness and fatigue, thirst, darken of facial skin and red spots on the left forehead. After a course of medication, these main symptoms disappeared and the medication was stopped.

[0099] On Oct. 26, 2001, the main symptoms reappeared and he decided to continuously use this medication and enrolled into this trial. The main symptoms disappeared again, including red spots on the left forehead, and have not recurred again so far (May 2002).

[0100] 2. No.5, Mr. Chiang, Born in 1929, Male

[0101] After being diagnosed as hepatoma in a hospital of the 2^(nd) grade on September 1998, he was admitted into hospital and has accepted one thrombosis procedure.

[0102] On Nov. 22, 1998, he was enrolled into this trial and his main symptoms are swelling of right costal area, abdominal illness, skin itchiness, insufficient strength, movement difficulty, dizziness and unable to stand, and lost of appetite. On December 7, during the first course of treatment, such symptoms were significantly alleviated and the original hospital urged him to go back for checking.

[0103] On Apr. 3, 1999, 120 days after the treatment, he was back to receive this medication due to the deterioration, insufficient strength, sharp pain of right costal region and hardness of tumor area and his symptoms were significantly improved on April 17, during the second course of treatment. On May 3, the pain was mild and occasional and his tumor mass has become soft.

[0104] 3. No. 8, Mr. Lee, Born in 1941, Male

[0105] After being diagnosed as hepatoma (5.5 cm) in a religious hospital of the 2^(nd) grade on May 1998, he was admitted into the hospital and transferred to a teaching hospital of the 1^(st) grade on May 2 for a hospitalization of 34 days. The original swelling has been dispersed, however, with no improvement for other symptoms.

[0106] He started to receive this medication from on Jul. 7, 1998, and his main symptoms at that time included pain and swelling at the right costal region, emaciation, tiredness and fatigue, and weary movement, as well as high blood pressure and gout. On August 5, during the first course, local pain and gout has vanished and protein inversion has been reduced.

[0107] On Nov. 29, 1998, his vitality, physical strength and life were as normal and he joined a travel group to Mainland China. On Mar. 2, 1999, during a group tour to southern part of this island, he complained a weakness of feet and shin and occasional sprain and his AFP decreased from 1200 to 205. A further improvement on his condition was observed on June 19.

[0108] 4. No. 18, Mr. Lin, Born in 1967, Male

[0109] After being diagnosed as hepatoma (8.0 cm) in a hospital of the 3^(rd) grade on June of 1999, he was transferred to another two teaching hospitals of the 1^(st) grade for conformation. He has undergone twice of thrombosis procedures and scanned again at the mid November in a southern teaching hospital of the 1^(st) grade. The scan results showed that tumor has already metastasized to lung and inoperable.

[0110] He started to receive this medication on December 2 of 1999, and his main symptoms included occasional pain, back pain and numbness at the right costal region, pain at the lower right shoulder, and skin rashes without itching. On December 14, during the first course, these main symptoms have been significantly improved. On January 11 of 2000, tumor mass has been proven to be contracted by scanning, however, lung was slightly enlarged.

[0111] On March 29 of 2000, the original tumor has contracted from 8.0 cm to 3.6 cm without any change for lung.

[0112] 5. No. 23, Miss Zhuo, Born in 1961, Female

[0113] After being screened and diagnosed as sigmoid colon cancer in a hospital of the 2^(nd) grade in central Taiwan on August of 1998, she has undergone a partial dissection right away. In the follow-up at October, tumor has metastasized to intrahepatic bile duct with a size of about 2.0 cm. She has received three times of chemotherapy in time, however, her condition continued to deteriorate.

[0114] She started to receive this medication on January 19 of 1999, and her main symptoms included numbness and pain of right costal region, shoulder and back with a radiation towards outside, irregular breathing in chest, sharp pain of local surgical area while coughing and occasional constipation. On February 3, during the first course of treatment, the main symptoms have been improved. On April 22, tumor on intrahepatic bile duct has significantly contracted to as 1.3 cm proven by scan and the main symptoms disappeared.

[0115] 6. No. 25, Miss Hu, Born in 1954, Female

[0116] After being screened and diagnosed as ovary cancer in a military hospital of the 2^(nd) grade in southern Taiwan on November of 1999, she has undergone a surgery to remove the ovary and surrounding lymph nodes (her uterus has been removed at 9 years age due to myoma. She had another surgery at May 11, 2000 to dissect a 7 cm of intestine due to metastasis. Not for a long time, via scanning in a hospital of the 2^(nd) grade, a metastasized tumor of 0.9 cm was found in liver and her condition was deteriorating. In fear of another operation, she refused to have chemotherapy or radiation therapy. According to doctors of these 3 hospitals, she may die before June of 2000 if doing nothing.

[0117] She started to receive this medication on Apr. 21, 2000 in a critical condition. Based on the experience, tumor may have already metastasized into bones and her main symptoms included local mass, swelling and pain at lower abdomen, indigestion and gas accumulation at stomach, sour and pain and being unable to lift of right shoulder, pain of right costal region and chest, swelling and hardness of legs, tiredness and gasping, insufficient physical energy, and hindrance in urination and excretion.

[0118] After taking this medication, her main symptoms were significantly alleviated or even disappeared. Although her condition was undulated due to the complexity or accidental infections, all could be alleviated by this medication. Her CA125 level was back to normal from original 44.1, so did CEA, which is maintained below the normal levels. At the end of trial, she was near normal and still alive now (May 26, 2002).

[0119] 7. No. 30, Mr. Hao, Born in 1960, Male

[0120] After being diagnosed as hepatoma in a famous hospital of the 2^(nd) grade in southern Taiwan on February of 1999, he has undergone a surgery for dissection and stayed in that hospital for treatments and follow-up. On September 7 of 2000, he collapsed due to sharp pain of right costal region and checked in-the Emergency Department of the original hospital. However, doctors reckoned that several tumors have recurred and liver transplantation was impossible. He could only depend on regularly take drug for anesthesia to relieve pain.

[0121] He started to receive this medication on September 13 of 2000. His main symptoms included persistent and sever pain at right costal region, indigestion of stomach and swelling of abdomen, constipation (only 4 times in a month) with scattered stool, but normal urination. On September 24, during the first course of treatment, severe pain has vanished to skip the usage of anesthesia and the swelling has amended.

[0122] On October 7 of 2000, he has transferred to a teaching hospital of the 1^(st) grade in northern Taiwan for examination. His condition has been proven to be greatly improved and thrombosis and chemotherapy were applicable.

[0123] 8. No. 42, Mr. Chen, Born in 1959, Male

[0124] After being diagnosed as hepatoma complicated with liver cirrhosis in a religious hospital of the 2^(nd) grade in southern Taiwan in April of 1998, he was transferred to another hospital of the 2^(nd) grade on April 9 for thrombosis procedure but the condition was still deteriorating.

[0125] He started to receive this medication on April 19 of 1998. His main symptoms included occasional pain at right costal region, swelling and indigestion of stomach and swelling of feet, tiredness and lack of strength, and yellow-brownish facial skin. On May 1, during the first course of treatment, the main symptoms have been improved and on May 13, further improved since the liver tumor was dispersed as seen in scan. On December 27, all symptoms have all vanished and his spirit and physical strength has back to normal.

[0126] 9. No. 44, Mr. Chen, Born in 1962, Male

[0127] After being diagnosed as hepatoma in a hospital of the 2^(nd) grade in southern Taiwan in March of 1997, his condition has been slightly improved after treatment. On October 20 of 1999, he admitted into a public hospital for examination due to haematemesis and the results showed a recurrence hepatoma of 3.7 cm.

[0128] He started to receive this medication on November 11 of 1999. His main symptoms included occasional pain at right costal region, indigestion of stomach, poor appetite, one excretion in 2 to 3 days and yellowish urination. On November 25, the pain of right costal region has alleviated and the swelling of stomach has vanished. The scan performed on January 13 of 2000 has shown that the recurred tumor mass of 3.7 cm has significant reduced with no sign of tumor cells.

[0129] Concluded from abovementioned, this invention, one medication combination for hepatoma and pancreatic cancer, is based on continuing novel theories, including “A theory on birth, growth, aging and death of a creature”, “A theory on the developing environment of a creature”, “A theory on surrounding pathology of cancer”, and “A theory on the relationship of six elements and pathology in a creature” to utilize “the nature and tendency of medication” to generate a repulsive environment for cancer cells via a way of “soft conquers tough” complying with the principle of nature. Therefore, the goal of curing the cancer is achieved. Such theory and remedy are invented by this inventor, which are the characteristics of this invention and different from the conventional views and remedies of “resistance, killing, and extermination of cancers”. Furthermore, the medications and their ratios as listed in the claims are made of concentrated and extracted powder for the purposes of quick effects and preciseness. However, the crude preparation, decoction, and preparations for oral and intravenous injection with cancer curing effects are still included this claim. The practical subject in this clinical trial Condition before trial: Precedent treatments and results Cancer type: hepatoma Name of subject: Mr. Zin-Su Wang Original number of case: 98032102 Date of birth: 1947 The hospital making diagnosis: Address: Dunggang, Pingtung Hsien Chang Gung Hospital in Kaohsiung Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: March, 1998 Place of hospital: Kaohsiung Shien, Taiwan Diagnosis: hepatoma with a tumor of 2.0 cm, liver cirrhosis and hepatic coma Main cancer-related symptoms: Hepatic coma while hospitalized in the original Pain of right costal region and swelling of stomach hospital. Pre-administration of medication was Other minor symptoms: requested and officially enrolled into this trial after Tiredness and fatigue, unsolidified stool of twice a regaining conscious. day, and frequent micturition of small amount This subject has enrolled into this trial since Apr. 14, 1998 till Aug. 27, 1998 for a total of 6 courses and 76 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 7 of 1998, frequency of pain of the right Determination of efficiency: with efficiency costal region has reduced and the severity of swelling Filed on Mar. 15, 2002 of stomach has amended. His condition has further improved on May 21 and stabilized on July 11 with solidified stool and better spirit. The medication was discontinued on August 15 for 22 days. Due to drinking, his stomach swelled again but no pain in the right costal region. The medication was continued for 12 days. Cancer type: pancreatic cancer with metastasis Name of subject: Mr. Ching-Guy Wang Original number of case: 01031521 Date of birth: Mar. 6, 1932 The hospital making diagnosis: Pingtung Christian Address: Yanpu, Pingtung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, CT and ultrasonic scan, and Date of diagnosis: Mar. 12, 2001 endoscopegraphy Place of hospital: Pingtung Hsien, Taiwan Diagnosis: (1) pancreatic cancer diagnosed by Pingtung Christian Hospital (2) cancers metastasized to pancreas, liver, stomach and duodenum as diagnosed by Chang Gung Hospital Main cancer-related symptoms: hindrance in upper He was hospitalized with an implantation of a bile digestive tracts and stomach and continuous hiccup after catheter. This execution unit was informed on meals, as well as numbness and tightness in right costal March 15 and he was treated for a total of 3 times area with medications for 15 days. Other minor symptoms: tiredness and fatigue, thirst, On April 17, he was transferred to Chang Gung darken of facial skin and red spots on the left forehead. Hospital for a surgical dissection of gallbladder, pancreatic-bile duct, a part of pancreas, duodenum (about 2 inches), and stomach (1/2) since all abovementioned areas have been metastasized by cancer cells. This subject has enrolled into this trial since Mar. 15, 2001 till Feb. 27, 2002 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 10, 2001, he officially came in for seeking Determination of efficiency: treatment. After a course of medication, these main Significant efficiency symptoms disappeared and the medication was stopped. Filed on Mar. 15, 2002 On October 26 of 2001, the main symptoms reappeared and he decided to continuously use this medication and enrolled into this trial. On January 16, the main symptoms disappeared again, including red spots on the left forehead. Stayed in the trial. Cancer type: nodular hepatoma Name of subject: Mr. Kuo-Ping Wang Original number of case: 99021114 Date of birth: Sep. 24, 1945 The hospital making diagnosis: Kaohsiung Medical Address: Gushan District, Kaohsiung City University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: October, 1998 Place of hospital: Kaohsiung City Diagnosis: nodular hepatoma, fatty liver, HBV carrier and vesicle in right kidney Main cancer-related symptoms: occasional pain and Unknown tenderness of right costal region, swelling of stomach Other minor symptoms: incomplete urination, salivation and burning under feet This subject has enrolled into this trial since Feb. 11, 1999 till Mar. 30, 1999 for a total of 3.5 courses and 42 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 3, 1999 during the 2^(nd) course, pain of right Determination of efficiency: significant efficiency costal region has vanished and the swelling of Filed on Mar. 15, 2002 stomach has amended. On Mar. 25, 1999 during the 3^(rd) course, the main symptoms have vanished, but the minor symptoms were unstable. Cancer type: hepatoma with metastasis Name of subject: Mr. Huo-Yan Chiang Original number of case: 01032201 Date of birth: Jan. 10, 1937 The hospital making diagnosis: Keelung Chang Gung Address: Chidu District, Keelung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: October, 1996 Place of hospital: Keelung City, Taiwan Diagnosis: hepatoma with 1 tumor of 2.0 cm, in 1998, 2 in left lobes and 3 in right lobes recurred Main cancer-related symptoms: occasional pain of the In 1996, 2 tumors were detected and alcohol right costal region and swelling of stomach, as well as chemotherapy was performed on October. Another 3 abnormal sound during respiration and constriction tumors were recurred in April 1998. Thrombosis was during deep respiration performed in October, 1998 and January 2001 and the Other minor symptoms: tiredness and fatigue, dryness AFP value ranged between 7,000 and 4,300. On in mouth and tongue, and frequent micturition during Mar. 27, 2001, AFP elevated to 50,000 and on the night March 31, multiple tumors were discovered by ultrasonic scan. This subject has enrolled into this trial since Mar. 22, 2001 till Jun. 19, 2001 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Apr. 1, 2001, the main symptoms have been Determination of efficiency: with efficiency improved and the diagnosis reports dated on March Filed on Mar. 15, 2002 27 and 31 of the original hospital were informed. On April 16 and May 1, the main symptoms were continuously improved but limited improvement on the minor symptoms. On May 16, the main symptoms were continuously improved with a pc of 270 and AFP has decreased from 50,000 to 23,950. On June 5, results of laboratory examinations were informed and the condition was not deteriorating with an AFP of 25,405. Cancer type: hepatoma Name of subject: Mr. Tan-Tsai Chiang Original number of case: 98112201 Date of birth: Oct. 14, 1929 The hospital making diagnosis: An Tai Hospital, Address: Shinbei, Pingtung Hsien Dunggang Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: September, 1998 Place of hospital: Pingtung Hsien, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: After being diagnosed as hepatoma, he was admitted swelling of right costal area, abdominal illness, skin into hospital and has accepted thrombosis procedure itchiness twice. Other minor symptoms: Insufficient strength, movement difficulty, dizziness and unable to stand, and lost of appetite. This subject has enrolled into this trial since Nov. 22, 1998 till Jun. 14, 1999 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On December 7, during the first course of treatment, Determination of efficiency: with efficiency all symptoms were significantly alleviated and the Filed on Mar. 15, 2002 original hospital urged him to go back for checking. The treatment has stopped for 120 days. On April 3 of 1999, he was back to receive this medication due to the condition deterioration, insufficient strength, sharp pain of right costal region and hardness of tumor area. On April 17, during the second course of treatment, the main symptoms were significantly improved. On May 3, the pain was mild and occasional and his tumor mass has become soft. Cancer type: hepatoma with metastasis in backbone Name of subject: Mr. Zao-Yon Lee Original number of case: 01122604 Date of birth: Sep. 18, 1942 The hospital making diagnosis: Cheng Gong Address: Jiading, Kaohsiung Hsien University Hospital, Tainan Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Nov. 28, 2001 Place of hospital: Tainan City, Taiwan Diagnosis: hepatoma metastasized to backbone after radiation, and liver cirrhosis. Main cancer-related symptoms: After confirmed diagnose, he was admitted into Sharp pain in the costal region and swelling of Cheng Gong University Hospital on November 28, abdomen, numbness and pain of left back, arms and 2001 for 12 times of radiation therapy. The cancer has feet, and movement difficulty. metastasized to spine and therefore, induced Other minor symptoms: lack of strength, incapability numbness and pain of lower body. of movement, difficulty in excretion and frequent micturition of small amounts. This subject has enrolled into this trial since Dec. 26, 2001 till Feb. 26, 2002 for a total of 5 courses and 60 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jan. 6, 2002, during the first course, the sharp Determination of efficiency: with efficiency pain of right costal region has alleviated, movement Filed on Mar. 15, 2002 difficulty has been improved with being able to lift the left foot. On January 20 and February 2, the pain of right costal region has vanished and other symptoms have been improved. On February 20, the swelling of abdomen has been alleviated. Cancer type: hepatoma Name of subject: Mr. Gin-Ying Lee Original number of case: 99090913 Date of birth: 1993 The hospital making diagnosis: Kaohsiung Medical Address: Lingya District, Kaohsiung City University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Sep. 7, 1999 Place of hospital: Kaohsiung City, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: Unknown Hard tumor mass, touched as stones, and occasional sudden pain in the right costal region and stomach, and swelling and complaint on both sides of abdomen. Other minor symptoms: movement difficulty of lower body during sleep, red urination and once or twice of excretion in a day. This subject has enrolled into this trial since Sep. 9, 1999 till Nov. 29, 1999 for a total of 4.5 courses and 54 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 24, 1999, the tumor mass at the right Determination of efficiency: with efficiency costal region and stomach were significantly Filed on Mar. 15, 2002 dispersed and soften. The sudden pain and swelling have been alleviated. On October 8, the tumor mass has been dispersed and moveable due to the softening and contracting. The main symptoms have been further alleviated. The medication has been stopped for 22 days after the condition improvement. The original hospital has asked him to visit for treatment, however, his condition has deteriorated. On November 14, he was back into this trial and the symptoms have been alleviated again. Cancer type: hepatoma Name of subject: Mr. Wang-Tsai Lee Original number of case: 98070701 Date of birth: Dec. 16, 1941 The hospital making diagnosis: National Taiwan Address: Luodung, Ilan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: nuclear examination and CT and Date of diagnosis: May 22, 1998 ultrasonic scan Place of hospital: Taipei City, Taiwan Diagnosis: hepatoma with a tumor of 5.5 cm, higher hepatic index, protein inversion, and lower RBC count Main cancer-related symptoms: Initially diagnosed and treated at Luodung Goddess Swelling and pain of right costal region and Hospital and then transferred to National Taiwan emaciation with darken skin University Hospital and stayed for 34 days. The Other minor symptoms: tiredness and fatigue, previous swelling was alleviated due to diarrhea, but frequent micturition of large amounts, lack of strength other symptoms were not improved. and complicated with hypertension and gout. This subject has enrolled into this trial since Jul. 7, 1998 till Jun. 19, 1999 for a total of 22 courses and 244 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jul. 18, 1998, the main symptoms have been Determination of efficiency: significant efficiency alleviated. Filed on Mar. 15, 2002 On August 5, the tiredness has been alleviated and local pain and gout has vanished with a albumin of 3.2, globulin of 3.9, and RBC of 3,850,000. The protein inversion was still present but has been reduced. On Nov. 29, 1998, his vitality, physical strength and life were as normal and he joined a travel group to Mainland China. On March 2 of 1999, during a group tour to southern part of this island, he complained a weakness of feet and shin and occasional sprain and his AFP decreased from 1200 to 205. A further improvement on his condition was observed on June 19 and his life and daily activity was as normal. Cancer type: hepatoma Name of subject: Mrs. Me-May Yu Original number of case: 98091212 Date of birth: Sep. 5, 1943 The hospital making diagnosis: Keelung Veteran Address: Keelung City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan, Date of diagnosis: Sep. 10, 1996 Place of hospital: Keelung City, Taiwan Diagnosis: hepatoma and liver cirrhosis, which was reconfirmed by National Taiwan University Hospital. Main cancer-related symptoms: occasional pain of the After a long-term treatment at National Taiwan right costal region, swelling of stomach and University Hospital with many times of thrombosis occasional vomitous feeing, swelling of feet and shin, procedures, her condition continued to deteriorate. and headache spreading to the brow. Tranquilizer was internally administrated for Other minor symptoms: sleep difficulty, constipation, removing the pain. and slight paralysis of the left side This subject has enrolled into this trial since Sep. 12, 1998 till Nov. 29, 1998 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 23, 1998, most main symptoms were Determination of efficiency: with efficiency alleviated, except sleep difficulty. Filed on Mar. 15, 2002 On October 25, pain of the right costal region has vanished and swelling and vomiting feeling have been significantly improved, as well as the swelling of feet and shin. On November 17, apart from hardness of lower abdomen, urination difficulty, and thirst, other symptoms have vanished or further improved. Cancer type: pancreatic adenocarcinoma (with Name of subject: Mrs. Show-Fong Yu metastasis to liver) Original number of case: 01010911 Date of birth: Mar. 18, 1962 The hospital making diagnosis: Kaohsiung Veteran Address: Fengshan, Kaohsiung Hsien General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: January, 2001 Place of hospital: Kaohsiung City, Taiwan Diagnosis: pancreatic adenocarcinoma of 4.0 cm and complicated with hepatoma, chronic hepatitis and gallbladder stones Main cancer-related symptoms: After a gallbladder dissection and implantation of a Swelling and pain of stomach, dryness in the mouth, bile catheter at the original hospital, he started to and salty or sour on the tongue, and hardness or pain receive this medication and while high fever or of the right costal region temporary symptoms, return to the original hospital Other minor symptoms: insufficient physical strength, for alternative treatment. tiredness and fatigue, dizziness and sleepless, lost of appetite, abnormal menses, pain in the intestine and hernia, as well as occasional cold with high fever This subject has enrolled into this trial since Jan. 9, 2001 till Feb. 12, 2002 for a total of 26 courses and 312 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On February 3, the man symptoms have alleviated, Determination of efficiency: with efficiency however, due to the internal injury from previous car Filed on Mar. 15, 2002 accident, dull pain of chest has occurred. On March 7, the main symptoms have been alleviated with sour on surface of tongue and heartburn. On March 24, in the follow-up at Veteran General Hospital, jaundice and liver function index were normal, sour on the surface of tongue has been amended, but with no menses, palpitation with fear, sleepless and pain of chest. On May 5, all symptoms were further improved. On August 4, occasional pain, contraction and hardness at the right costal region. On August 29, symptoms were amended and via scan at the original hospital, the tumor has been control with no deterioration. Minor symptoms and unexpected conditions of this patients were exceptional numerous and induce pain while severe. However, these were rapidly relieved after taking this trial medication. Cancer type: hepatoma Name of subject: Mr. Fu-Chan Song Original number of case: 00022903 Date of birth: Mar. 5, 1965 The hospital making diagnosis: Kaohsiung Veteran Address: Nantz District, Kaohsiung City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: nuclear examination and CT and Date of diagnosis: September 1999 ultrasonic scan Place of hospital: Kaohsiung City, Taiwan Diagnosis: With ultrasonic scan in September, CT scan in October, and NMR in February 2002, 4 hepatoma mass of 3.5 cm were detected with a complication of kidney failure, once or twice dialysis in a week. Main cancer-related symptoms: Unknown except long term dialysis Swelling or pain in the right costal region Other minor symptoms: tiredness and fatigue, sleepless, and lost of appetite This subject has enrolled into this trial since Feb. 29, 2000 till May 9, 2000 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 16, 2000, the condition has been improved Determination of efficiency: with efficiency with the vanishment of pain at the right costal region. Filed on Mar. 15, 2002 However, due to the vomiting at the previous day, there was illness in abdomen and thirst in mouth. On April 7, the pain of right costal region did not happen again, but still sleepless, lost of appetite, weak urination. However, the dialysis interval could be prolonged to once in 10 days. Cancer type: hepatoma Name of subject: Mr. Zong-Bai Wu Original number of case: 01072531 Date of birth: Jan. 20, 1927 The hospital making diagnosis: Kaohsiung Chang Address: Luye, Taitung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: Jul. 2, 2001 Place of hospital: Kaohsiung Hsien Diagnosis: a hepatoma of 5.0 cm, scanned first on July 2 at Liu Guang Shiong Hospital and reconfirmed by Chang Gung Hospital via biopsy. Main cancer-related symptoms: The previous medical record was absent. He directly Occasional and unclear pain of right costal region and join this trial and then referred to western treatment. backflow due to belch Other minor symptoms: tiredness and fatigue, lost of appetite, habitual constipation, and frequent and yellowish urination This subject has enrolled into this trial since Jul. 5, 2001 till Sep. 11, 2001 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Aug. 5, 2001, during the first course, main Determination of efficiency: with efficiency symptoms have been significantly alleviated. Filed on Mar. 15, 2002 On August 17, main symptoms have vanished. Cancer type: hepatoma Name of subject: Mr. Yue-Chiong Wu Original number of case: 01021606 Date of birth: Nov. 19, 1948 The hospital making diagnosis: Kaohsiung Chang Address: Niausung, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: June 2000 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: multiple radical hepatoma of small than 2.0 cm, complicated with hepatitis C. Main cancer-related symptoms: Accepted many courses of chemotherapy with Tightness and pain of right costal region, and swelling alcohol, and complicated with hypertension and of abdomen uremia with long-term administration of medication Other minor symptoms: frequent micturition of for treatment. normal amount This subject has enrolled into this trial since Feb. 16, 2001 till Apr. 13, 2001 for a total of 4.5 courses and 54 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 4, 2001, during the first course of Determination of efficiency: significant efficiency treatment, the condition has been amended. Filed on Mar. 15, 2002 On March 17, the condition has been further improved with vanishment of tightness and pain of right costal region and reduction of swelling of abdomen. On March 25, main symptoms have vanished without any recurrence. Cancer type: hepatoma Name of subject: Mr. Jin-Chang Wu Original number of case: 98081912 Date of birth: Feb. 21, 1928 The hospital making diagnosis: Kaohsiung Veteran Address: Yanpu, Pingtung Hsien General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, and CT and ultrasonic Date of diagnosis: July 1998 scan Place of hospital: Kaohsiung City, Taiwan Diagnosis: hepatoma progressed from liver cirrhosis Main cancer-related symptoms: The original diagnosis was liver cirrhosis, however, Hardness around the stomach (operation area of left during the surgical dissection of partial left lobe, liver lobe), which is like a inverted bowl, and cancer cells were detected. occasional dull pain Other minor symptoms: occasional numbness and pain of right shoulder and arms, tiredness and fatigue and sleepy This subject has enrolled into this trial since Aug. 19, 1998 till Jun. 30, 1999 for a total of 16 courses and 192 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 5, 1998, main symptoms were Determination of efficiency: with efficiency alleviated. Filed on Mar. 15, 2002 On September 19, his vitality was better, but with swelling in the lower abdomen and indigestion. On October 8, injury at the right costal region due to a fall. On Jun. 30, 1999, main symptoms have vanished and swelling of stomach has dispersed for 4/5. During the trial, due to numerous conditions, including a fall, a cold, or gout, the discontinuity of medication was longer, although the medication was efficient, and therefore, led to a long trial period. Cancer type: hepatoma Name of subject: Mr. Jin-Lang Wu Original number of case: 99111806 Date of birth: Jan. 12, 1950 The hospital making diagnosis: Ruan Surgical Address: Chianjen District, Kaohsiung City General Hospital, Kaohsiung Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: October 1999 Place of hospital: Kaohsiung City, Taiwan Diagnosis: tumor mass at the distal end of liver, ranging from 6 × 7 cm to 2.0 × 3 cm and complicated with diabetes Main cancer-related symptoms: On November 4, thrombosis procedure was Gasp and cough during respiration, leading to sharp performed for the large tumor mass of 6 × 7 cm at the pain of right costal region and occasional pain on Ruan Surgical General Hospital. both costal sides Other minor symptoms: tiredness and fatigue, frequent and massive amount of urination This subject has enrolled into this trial since Nov. 18, 1999 till Dec. 29, 1999 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Nov. 20, 1999, serious headache and high Determination of efficiency: significant efficiency fever occurred on the next day after the trial, due to Filed on Mar. 15, 2002 the spray of pesticide, and alternative medication was prescribed and administrated. On November 30, main symptoms were alleviated and accidental symptoms has been relieved. On December 5, the small tumor mass, which has not been through thrombosis procedure, has dispersed as proved by scanning at the original hospital. Cancer type: hepatoma (metastasized from Name of subject: Mr. An-Huei, Chiou nasopharyngeal cancer) Original number of case: 99092416 Date of birth: Jun. 23, 1941 The hospital making diagnosis: Chi-Mei Hospital, Address: Annan District, Tainan City Tainan Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, and CT and ultrasonic Date of diagnosis: August 1998 scan Place of hospital: Tainan City, Taiwan Diagnosis: nasopharyngeal cancer, which has metastasized as hepatoma as diagnosed in 1999) Main cancer-related symptoms: After being diagnosed as nasopharyngeal cancer, Swelling and pain of stomach and abdomen, burn and radiation and diathermy have been performed for 39 sweating of waist and back, swelling and lump at the cycles at the original hospital. In June 1999, the left costal region and tightness of chest tumor size was 4 × 4 cm in an ultrasonic scan, 5 × 6 cm Other minor symptoms: dryness in mouth and tongue after the treatment, and became 6.4 × 6 cm after 30 and short of saliva after diathermy, frequent days. micturition of small amount (once in a hour during the night), and constipation. This subject has enrolled into this trial since On August 3 and Sep. 2, 1999, AFP value was Sep. 24, 1999 till Nov. 24, 1999 for a 42.9 and 26.5, respectively. On September 25, before total of 3.5 courses and 42 days. the trial, AFP was 37.9 and on October 20, after the Trial procedure: trial, AFP was 34.0, which was stable and reduced. The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Oct. 6, 1999, swelling and pain of stomach Determination of efficiency: with efficiency and abdomen have alleviated, so did the tightness of Filed on Mar. 15, 2002 chest. On Oct. 21, 1999, his vitality was better and the pain has further alleviated. The swelling and hardness of left costal region has softened and dispersed. The medication has stopped from October 21 to November 12 for 16 days. He may go back to the hospital for treatment and the condition relapsed. On November 8, the medication was restarted again. Cancer type: hepatoma Name of subject: Mr. Yong-Tang Lin Original number of case: 01022432 Date of birth: Apr. 18, 1940 The hospital making diagnosis: Dali Ren-Ai Hospital, Address: Dali City, Taichung Hsien Taichung Hospital grade: general (the 3^(rd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: November 2000 Place of hospital: Taichung Hsien, Taiwan Diagnosis: hepatoma, swelling and prostate hypertrophy Main cancer-related symptoms: After the confirmation of diagnosis, thrombosis Swelling of right costal region and local varicosity, procedure was performed 3 times at the original swelling of feet and shin, swelling of abdomen with hospital, however, tumor mass was continuously reduced fart, and jaundice. enlarged and the conditions was deteriorating. Gastric Other minor symptoms: hemorrhage occurred during the second thrombosis Tiredness and fatigue, sleepless, atrophy of feet, skin procedure. itch, anus prolapse, prostate hypertrophy, and frequent micturition during the night This subject has enrolled into this trial since Feb. 24, 2001 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 8, 2001, the frequency of sudden pain of Determination of efficiency: with efficiency the right costal region was reduced, and pain, Filed on Mar. 15, 2002 swelling, and varicosity were alleviated. On March 22, swelling has vanished, blue veins only existed around the navel, and pain of right costal region has alleviated, but with tiredness, sleepiness and un-solidified stool. Cancer type: hepatoma (with metastasis to lung Name of subject: Mr. Zhi-Ming Lin cancer) Original number of case: 99120202 Date of birth: Mar. 1, 1967 The hospital making diagnosis: Linnei Hong-Yang Address: Linnei, Yunlin Hsien Hospital Hospital grade: general (the 3^(rd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Jun. 14, 1999 Place of hospital: Yunlin Hsien, Taiwan Diagnosis: hepatoma of 8.0 cm Main cancer-related symptoms: The diagnosis was reconfirmed by Kaohsiung Occasional pain of the right costal region, pain of the Medical University Hospital and Linko Chang Gung right arm and backache of the hepatic area. Hospital (both are teaching hospital of the 1^(st) grade), Other minor symptoms: and Dali Ren-Ai Hospital. After one thrombosis Skin pityriasis but not itchy procedure in July 1999 at Kaohsiung Medical University Hospital and once again on November 2 at Ren-Ai Hospital, he was referred to Kaohsiung Medical University Hospital. However, the cancer has metastasized to lung and inoperable. This subject has enrolled into this trial since Dec. 2, 1999 till October in a total of courses and days. Trial procedure: On Mar. 15, 2000, he called to inform us that the The medication combination, specific for treating hepatoma was disappeared but occasional pain of hepatoma and pancreatic cancer, is taken within 90 right costal region with a rise of AFP from 5000 to minutes after meals, that is 3 times a day for a total of 10,000. On Mar. 28, he informed us that the scan 12 gm. results of 2 hospitals were negative but one hospital has detected some spots. His pain of right costal region has vanished on June 7. On Dec. 14, 1999, main symptoms have been Determination of efficiency: with efficiency improved. Filed on Mar. 15, 2002 On Jan. 11, 2000, he informed us that via examination by Ren-Ai Hospital, tumor was significantly contracted and condition was improved with slight enlargement of lung. On Mar. 29, 2000, he informed us that hepatoma was contracted from 8.0 cm to 3.6 cm and lung was back to normal again Cancer type: hepatoma Name of subject: Mr. Wei-Shan Lin Original number of case: 10160603 Date of birth: Nov. 15, 1965 The hospital making diagnosis: Kaohsiung Ruan Address: Luju, Kaohsiung Hsien Surgical General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: May, 2000 Place of hospital: Kaohsiung City Diagnosis: hepatoma with metastasis to lung cancer Main cancer-related symptoms: After confirmation of diagnosis at Kaohsiung Women Pain of right costal region, hypersensitivity or pain at and Children Hospital in July 1999 and the esophagus of chest reconfirmation and operation at Ruan Surgical Other minor symptoms: General Hospital in May 2000, local cauterization Sleepless, and un-solidified stool for 2-3 times a day, was performed due to liver cirrhosis. He was admitted frequent and irregular yellowish urination. again due to the metastasis to lung cancer and treated with alcohol treatment, however, no efficient and hepatoma recurred. This subject has enrolled into this trial since Jun. 6, 2001 till Jan. 17, 2002 for a total of 11 courses and 132 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. During the initial treatment, all symptoms were Determination of efficiency: undetermined alleviated. Filed on Mar. 15, 2002 On Jul. 11, 2001, he was back to the hospital for follow-up and no recurrence was detected. Due to various reasons, he discontinue the medication several times. During the follow-up on Dec. 14, 2001, recurrence has been detected. Cancer type: intrahepatic bile duct cancer Name of subject: Mr. Fu-Zhu Lin Original number of case: 01061008 Date of birth: Aug. 6, 1947 The hospital making diagnosis: Kaohsiung Chang Address: Tianliau, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Jun. 17, 2001 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: 4 tumor mass, each of 6.0 cm, which was confirmed by Taipei He-Shin Hospital Main cancer-related symptoms: This patient was recommended for a recheck by big Occasional pain of right costal region and stomach, hospitals due to the suspicion of hepatoma from which was more serious during the night, and diagnosis on June 10 and 17 of 2001 (unrelated to this swelling of stomach without feeling hungry trial). The condition was not serious at the time. After Other minor symptoms: being diagnosed by big hospitals, he started this trial Frequent and yellowish urination, tiredness and as late as September 12 while his condition has fatigue, lack of strength of feet, movement difficulty, deteriorated as listed left. If any thrombosis procedure dizziness, vomit, and constipation with once in 3-4 or chemotherapy during these 3 months were days. unknown. This subject has enrolled into this trial since Sep. 12, 2001 till Jan. 9, 2002. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 12, 2001, after the trial, the condition Determination of efficiency: inefficiency was unstable and not much improved. At the end of Filed on Mar. 15, 2002 treatment, his condition was even worse. Cancer type: hepatoma Name of subject: Mr. Chuan-Yin Lin Original number of case: 98092601 Date of birth: Dec. 1, 1951 The hospital making diagnosis: Kaohsiung Chang Address: Yanpu, Pingtung Hsien Gung Hospital Hospital grade: Diagnosis method: CT and ultrasonic scan and Date of diagnosis: February, 1998 endoscopegraphy Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: radical hepatoma, hypertrophy of veins at the distal end of esophagus Main cancer-related symptoms: This patient was dumb and represented by the family. Swelling and pain of the right costal region, and slight After the confirmation of diagnosis, he was treated by pain of esophagus and right chest during swallow. thrombosis and chemotherapy at the original hospital. Other minor symptoms: Appetite, urination and excretion were normal This subject has enrolled into this trial since Sep. 26, 1998 till Jun. 5, 1999 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Oct. 10, 1998, after the first course, the Determination of efficiency: significant efficiency condition has been improved. Filed on Mar. 15, 2002 On Nov. 4, 1998, the main symptoms have vanished. On December 6, at the end of treatment, all symptoms did not recur. On Mar. 18, 1999, another 2 courses of treatment was given due to the pain at esophagus or pharynx during swallow. Cancer type: hepatoma Name of subject: Mr. Zheng-Liang Zhou Original number of case: 01030806 Date of birth: Jul. 10, 1940 The hospital making diagnosis: Pingtung Christian Address: Fengshan, Kaohsiung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Feb. 5, 2001 Place of hospital: Pingtung City, Taiwan Diagnosis: a hepatoma of 4.6 cm, referred to Chang Gung Hospital on February 9 and scanned on March 8 with a tumor of 4.9 cm Main cancer-related symptoms: After referring to Chang Gung Hospital on Feb. 9 Hardness and tightness of the right costal region, 2001, due to the weakness of patients and the stuffiness or pain of stomach and chest enormous size of tumor, thrombosis procedure was Other minor symptoms: difficult and too risky to performe. Insufficient physical strength, poor appetite, constipation, frequent micturition and Parkinson's disease This subject has enrolled into this trial since Mar. 8, 2001 till Apr. 26, 2001 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 21, 2001, main symptoms has been Determination of efficiency: with efficiency alleviated, so did the minor symptoms. From the scan, Filed on Mar. 15, 2002 hepatoma has contracted and hepatic function index, except ALT/AST, was reduced for performing the thrombosis procedure. On Apr. 4 and 10, 2001, conditions were further improved. Cancer type: hepatoma (metastasized from sigmoid Name of subject: Mrs. Jin-Lian Zhuo cancer) Original number of case: 99011911 Date of birth: Aug. 26, 1961 The hospital making diagnosis: Shalu Kuang-Tian Address: Chingshuei, Taichung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: August 1998 Place of hospital: Taichung Hsien, Taiwan Diagnosis: sigmoid cancer and after the dissection, a metastasized tumor of 2.0 cm was to intrahepatic bile duct Main cancer-related symptoms: After dissection of sigmoid cancer in August 1998, a Numbness and pain, which was radial outward, of metastasized tumor of 2.0 cm was found in the right costal region, shoulder and back, stuffiness of intrahepatic bile duct, 3 courses of chemotherapy chest, sharp pain at the local operation area (intestine) were performed right after. during cough Other minor symptoms: Occasional constipation This subject has enrolled into this trial since Jan. 19, 1999 till Nov. 23, 2000 for a total of 10 courses and 120 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 2, 1999, main symptoms have been Determination of efficiency: significant efficiency alleviated. Filed on Mar. 15, 2002 On Mar. 2, 1999, symptoms were further improved. On Apr. 22, 1999, the metastasized tumor has shrunk to only 1.3 cm as seen by scanning and main symptoms have vanished Cancer type: intrahepatic bile duct cancer Name of subject: Mrs. Yang-Zhi Zhuo Original number of case: 01020806 Date of birth: Nov. 20, 1949 The hospital making diagnosis: Linko Chung Gang Address: Chingshuei, Taichung Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: biopsy Date of diagnosis: November 2000 Place of hospital: Taipei Hsien, Taiwan Diagnosis: intrahepatic bile duct cancer and recurrence after dissection Main cancer-related symptoms: The tumor recurred after dissection. From Dec. Jaundice and pain of right costal region due to 15, 2000, chemotherapy was performed for 6 courses implantation of catheter, swelling of abdomen and and tumor was still enlarged with significant stomach, stuffiness, unclear pain at the navel, and deterioration of hepatic function, anesthesia and ache of shoulder, arms and back tranquilizer were needed due to the unbearable pain. Other minor symptoms: Dizziness, tiredness and fatigue, movement difficulty, sleepless, thirst, and lost of appetite This subject has enrolled into this trial since Feb. 8, 2001 till Jul. 19, 2001 for a total of 8 courses and 96 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 20, 2001, the condition was severe. Determination of efficiency: inefficiency On Mar. 7, 2001, main symptoms were greatly Filed on Mar. 15, 2002 improved. Sharp pain of right costal region recurred after 5 courses of treatment. On May 3, 2001, he informed us that tumor was found to be slightly larger through a scan at Chang Gung Hospital. Cancer type: hepatoma (metastasis of ovary cancer Name of subject: Mrs. Gui-Zhu Hu and intestine cancer) Original number of case: 00042111 Date of birth: Apr. 23, 1954 The hospital making diagnosis: Kaohsiung Veteran Address: Sanmin District, Kaohsiung General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: November 1999 Place of hospital: Kaohsiung City, Taiwan Diagnosis: ovary cancer which metastasized to intestine and liver after dissection Main cancer-related symptoms: After undergone a surgery on Dec. 6, 1999 to Local lump of abdomen, swelling and pain of remove the ovary and surrounding lymph nodes (her abdomen, ache of right shoulder and arm, movement uterus has been removed at 9 years age due to difficulty, pain of costal region and chest, and myoma, she had another surgery at May 11 2000 to swelling of feet and shin. dissect a 7 cm of intestine due to metastasis. Not for a Other minor symptoms: long time, via scanning at Ruan Surgical Hospital, a Tiredness and easy to gasping, insufficient strength, metastasized tumor of 0.9 cm was found in liver and incomplete urination and obstruction of excretion her condition was deteriorating. According to doctors of Veteran General Hospital and Chung Gung Hospital, she may die before June of 2000 if without treatment. This subject has enrolled into this trial since Apr. 21, 2000 till Dec. 27, 2001 for a total of 48 courses and 576 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. After taking this medication, her main symptoms Determination of efficiency: significant efficiency were significantly alleviated or even disappeared. Filed on Mar. 15, 2002 Although her condition was undulated due to the complexity or accidental infections, all could be alleviated by this medication. Her CA125 level was back to normal from original 44.1, so did CEA, which is maintained below the normal levels till the end of trial. Cancer type: hepatoma Name of subject: Mr. Zhu Hong Original number of case: 01021511 Date of birth: 1929 The hospital making diagnosis: MacKay Memorial Address: Houlung, Miaoli Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Sep. 10, 2001 Place of hospital: Taipei City, Taiwan Diagnosis: a hepatoma of 10 cm complicated with hypertension Main cancer-related symptoms: Hardness and local persistent pain of right costal region, and swelling of abdomen and shin Other minor symptoms: Lost of appetite and obstructed urination This subject has enrolled into this trial since Feb. 15, 2001 till Mar. 22, 2001 a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Apr. 24, 2001, persistent pain of the right costal Determination of efficiency: inefficiency region has been significantly improved with a normal Filed on Mar. 15, 2002 blood pressure. On Mar. 15, 2001, condition was stable without any further improvement. Cancer type: hepatoma Name of subject: Mr. Jin-Lai Hon Original number of case: 98010712 Date of birth: Jul. 22, 1955 The hospital making diagnosis: Luju Wen Surgical Address: Luju, Kaohsiung Hsien Hospital Hospital grade: general (the 3^(rd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: 1997 Place of hospital: Ksohsiung Hsien, Taiwan Diagnosis: hepatoma with liver cirrhosis and AFP over 1000 Main cancer-related symptoms: Directly enrolled into this trial Occasional swelling and pain of the right costal region and subacute jaundice Other minor symptoms: Tiredness and fatigue, sleepless, and yellowish urination This subject has enrolled into this trial since Jan. 7, 1998 till Apr. 25, 1998 for a total of 6 courses. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jan. 20, 1998, main symptoms were Determination of efficiency: with efficiency alleviated. Filed on Mar. 15, 2002 On Jan. 27, due to the cold and cough, alternative “Shuang Jie San” was administrated. On Feb. 12, 1998, main symptoms were further alleviated as confirmed by Tainan County Hospital, and main symptoms have vanished before the end of treatment. Cancer type: hepatoma Name of subject: Mrs. Lai-Mei-Gui Chiang Original number of case: 01091603 Date of birth: Apr. 2, 1936 The hospital making diagnosis: Ren-Ai Hospital, Address: Shiaying, Tainan Hsien Taipei Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: April 2000 Place of hospital: Taipei City, Taiwan Diagnosis: hepatoma with a large one of 4 cm and numerous small ones from 2 to 10 cm, complicated with hypertension Main cancer-related symptoms: After 3 thrombosis procedures being performed at the Pain of the right costal region, swelling of stomach, original hospital, the patient's condition still stuffiness of chest and abdominal swelling deteriorated. Other minor symptoms: Tiredness and fatigue, lost of appetite, constipation, obstructed urination and weakness This subject has enrolled into this trial since Sep. 16, 2001 till Nov. 20, 2001 for a total of 5 courses and 60 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On September 28, during the first course, main Determination of efficiency: with efficiency symptoms were greatly improved, however, urination Filed on Mar. 15, 2002 was still obstructed and waist was too weak to sit for long. On Oct. 11, 2001, abdominal swelling was alleviated and no obstruction for urination and excretion. At the end of treatment, main symptoms were greatly improved with the vanishment of swelling. Cancer type: hepatoma Name of subject: Mr. Wen-Shan Hou Original number of case: 01021613 Date of birth: Oct. 21, 1941 The hospital making diagnosis: National Chung Gung Address: Beimen, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Feb. 16, 2001 Place of hospital: Tainan City, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: After the confirmation of diagnosis, the patient was Stuffy pain and sudden pain of right costal region, enrolled into this study. which was even severe during the night, chest pain On Apr. 4, 2001, after the improvement of condition, and cough the original hospital asked the patient to go back for Other minor symptoms: unknown treatment. Obstructed and unsolidified excretion, frequent micturition of small amount and sleepless This subject has enrolled into this trial since Feb. 16, 2001 till Apr. 28, 2001 for a total of 6 courses. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 16, 2001, during the first course, main Determination of efficiency: with efficiency symptoms were improved and further improved on Filed on Mar. 15, 2002 Mar. 8, 2001. On Mar. 22, 2001, via the scan at the original hospital, tumor was stable and slightly shrunken with a decrease of AFP from 242 to about 100. Cancer type: hepatoma Name of subject: Mr. Wei-Zhang Hou Original number of case: 00091312 Date of birth: Apr. 17, 1960 The hospital making diagnosis: Kaohsiung Chang Address: Putz, Chiai Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: February 1999 Place of hospital: Kaohsiung Hsien Diagnosis: hepatoma, which recurred after the dissection Main cancer-related symptoms: sharp pain of the In the middle of February 1999, he underwent a right costal region (heavy sweating if happen), and surgery for removing hepatoma and stayed in the enormous swelling of stomach and abdomen original hospital for treatment and follow-up. On Other minor symptoms: unsolidifled excretion of 4 September 7 of 2000, he collapsed due to sharp pain times a day but normal urination of right costal region and checked in the Emergency Department of the original hospital. However, doctors reckoned that nothing could be done and transplantation was impossible. This subject has enrolled into this trial since Sep. 13, 2000 till Oct. 19, 2000 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On September 24, during the first course of treatment, Determination of efficiency: significant efficiency, severe pain has vanished and the swelling has efficiency, no efficiency and undetermined amended. Filed on Mar. 15, 2002 On October 7 of 2000, he has transferred to National Taiwan University Hospital for examination. His condition has been greatly improved and thrombosis and chemotherapy were applicable. Cancer type: hepatoma Name of subject: Mr. Rong-Zhou Kuo Original number of case: 99071406 Date of birth: Feb. 3, 1943 The hospital making diagnosis: Kaohsiung Chang Address: Nantz District, Kaohsiung City Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: Jun. 10, 1999 Angiography Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: diagnosed by CT scan at Veteran General Hospital on May 1 1999, and confirmed by angiography at Chang Gung Hospital. Main cancer-related symptoms: 3 hepatoma masses, including two big ones of 6.0 cm Occasional swelling and pain of the right costal and one small one of 1.8 cm, were detected with region, frequent and yellowish urination of small complication of liver cirrhosis. Thrombosis procedure amount, and swelling of shin was performed at Chang Gung Hospital. AFP level Other minor symptoms: was normal with low platelet count and hepatic index Tiredness and fatigue of much too higher. This subject has enrolled into this trial since Jul. 14, 1999 till Dec. 12, 1999 for a total of 8 courses and 96 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jul. 26, 1999, main symptoms have been Determination of efficiency: significant efficiency improved. Filed on Mar. 15, 2002 On August 10, frequent micturition of little amount during the night. On September 26, during the treatment course, hospitalization due to esophagus hemorrhage. On October 9, hepatic index has dropped and platelet count has increased to normal. On October 19, via a scan at Chang Gung Hospital, large tumor mass has gradually dispersed with the vanishment of small tumors. Hepatic function has been improved and maintained till the end of treatment. Cancer type: hepatoma Name of subject: Mr. Yong-Chin Liang Original number of case: 98122514 Date of birth: Dec. 25, 1947 The hospital making diagnosis: Kaohsiung Chang Address: Chianjen District, Kaohsiung City Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan, and Date of diagnosis: April 1998 Angiography Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: initially diagnosed at Tainan City Hospital and then confirmed and treated with thrombosis procedure at Chung Gung Hospital. Main cancer-related symptoms: Thrombosis procedures were performed 5 times at Pain of the right costal region Chung Gung Hospital. Other minor symptoms: Dizziness, fatigue, twice or three times of excretions in a day, and sleeping difficulty This subject has enrolled into this trial since Dec. 25, 1998 till Apr. 10, 1999 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jan. 9, 1999, main symptoms were alleviated Determination of efficiency: with efficiency and then vanished on January 24. Filed on Mar. 15, 2002 On Feb. 13, all symptoms were disappeared with a normal hepatic index. Till the end of trial, he was in health condition. Cancer type: hepatoma Name of subject: Mrs. Shu-Fen Show Original number of case: 00091511 Date of birth: Jul. 30, 1963 The hospital making diagnosis: Kaohsiung Chang Address: Sanmin Distric, Kaohsiung City Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: March 2000 Angiography Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: a tumor mass of 3 × 4 cm at the right liver lobe and × 3 of the left lobe. Main cancer-related symptoms: After the confirmation of diagnosis, thrombosis Occasional stuffiness of the right costal region and procedure was performed for the tumor of 3 × 4 cm of back and feeling empty and hungry of the stomach the right lobe for 3 times. Other minor symptoms: Tiredness and lack of strength This subject has enrolled into this trial since Sep. 16, 2000 till Nov. 15, 2000 for a total of 4.5 courses and 54 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On September 27, main symptoms were alleviated Determination of efficiency: with efficiency and further alleviated on October 14. Filed on Mar. 15, 2002 On Nov. 3, 2000, via a scan at Chang Gung Hospital, the previous plugged tumor did not deteriorate anymore, no new tumor occurred and the small one disappeared. Cancer type: hepatoma Name of subject: Mrs. Yue-Li Chen Original number of case: 01032803 Date of birth: May 16, 0936 The hospital making diagnosis: National Cheng Kung Address: Lioying, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Mar. 26, 2001 Place of hospital: Tainan Hsien, Taiwan Diagnosis: a tumor of 11 cm was detected by screening at Ming Sheng Clinic, Lioujia, and then confirmed by Cheng Kung University Hospital Main cancer-related symptoms: Long usage of drugs for lowering blood pressure and Swelling of large area at the right costal region and sleeping pills. abdomen with occasional pain Other minor symptoms: Heart function difficulty, hypertension, burning pain of back chest, frequent micturition and constipation. This subject has enrolled into this trial since Mar. 28, 2001 till Sep. 12, 2001. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Apr. 18, 2001, the swelling of right costal and Determination of efficiency: significant efficiency abdominal region has gradually softened. Filed on Mar. 15, 2002 On May 30, 2001, the swelling of right costal and abdominal region has softened and contracted to only 1/2. At the end of trial, minor symptoms were alleviated due to medication administration, but relapsed soon after. The pain of the right costal and abdominal region has vanished. Cancer type: hepatoma Name of subject: Mr. Zhi-Qing Chen Original number of case: 99052201 Date of birth: Aug. 26, 1945 The hospital making diagnosis: Pingtung Christian Address: Pingtung City, Pingtung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Mar. 18, 1999 Place of hospital: Pingtung City, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: Transferred to Ren-Ai Hospital (the 3^(rd) grade) for A protruding tumor at the stomach, hard as stone and treatment and rechecked on May 15, 1999. pain while touch and swelling of stomach Other minor symptoms: Sleepless, thirst and weakness of feet This subject has enrolled into this trial since May 22, 1999 till Jun. 9, 1999 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 28, 1999, main symptoms were slightly Determination of efficiency: undetermined alleviated and not much improved by following Filed on Mar. 15, 2002 treatment. It was known later that patients have used alternative medication. Cancer type: hepatoma Name of subject: Mrs. Hong-Yun Chen Original number of case: 99051608 Date of birth: Oct. 21, 1937 The hospital making diagnosis: Kaohsiung Chang Address: Gangshan, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: November, 1998 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: a big hepatoma of 3.0 cm and a small one of 2.0 cm, complicated with liver cirrhosis Main cancer-related symptoms: One thrombosis procedure and twice alcohol Swelling of stomach and abdomen, and occasional injections at Chang Gung Hospital pain, which was more severe during the night Other minor symptoms: This subject has enrolled into this trial since May 16, 1999 till Sep. 8, 1999 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jun. 20, 1999, via a CT scan at Chung Gung Determination of efficiency: inefficiency Hospital, intrahepatic tumor has shrunken, however, Filed on Mar. 15, 2002 swelling of stomach and abdomen was alleviated till July 1. Cancer type: radical hepatoma Name of subject: Mr. Ching-Rong Chen Original number of case: 97080902 Date of birth: Apr. 15, 1927 The hospital making diagnosis: Tainan City Hospital Address: Annan District, Tainan City Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, CT and ultrasonic scan, Date of diagnosis: February 1997 and Angiography Place of hospital: Tainan City, Taiwan Diagnosis: radical hepatoma and HBV carrier, similar diagnosis after treatment at Kaohsiung Medical University Hospital Main cancer-related symptoms: Due to the senility and weakness of patient, the Tiredness and fatigue, drowsy and insignificant main original hospital did not perform thrombosis symptoms procedure and then transferred to Kaohsiung Medical Other minor symptoms: University Hospital for unknown treatment. Abnormality of prostate This subject has enrolled into this trial since Aug. 9, 1997 till Oct. 24, 1997 for a total of 5 courses and 60 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. Main symptoms were insignificant and the alleviation Determination of efficiency: inefficiency of minor symptoms was not due to the effect of this Filed on Mar. 15, 2002 trial medication (alternative medication was supplemented). This patient's vitality and physical strength were not improved. Cancer type: hepatoma Name of subject: Mr. Chong-Kuang Chen Original number of case: 97111608 Date of birth: Aug. 6, 1944 The hospital making diagnosis: Kaohsiung Chang Address: Fengshan, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan, and Date of diagnosis: May 1997 Angiography Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: hepatoma, liver cirrhosis and HBV carrier, FPE was 696 while examined in 1997 Main cancer-related symptoms: The patient worked at the 3^(rd) nuclear plant where 4 Slight pain of the right costal region and abdominal workers had diagnosed with cancer with 2 deaths in swelling recent time. After the diagnosis, he stayed in the Other minor symptoms: original hospital for thrombosis procedure and other Frequent and yellowish urination of small amount, necessary treatments. swelling of shin, and thirsty but not wanting drinking This subject has enrolled into this trial since Nov. 16, 1997 till Apr. 12, 1998 for a total of 10 courses and 120 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm On Nov. 30, 1997, pain of the right costal Determination of efficiency: with efficiency region has reduced but abdomen still swelled. Filed on Mar. 15, 2002 On Jan. 24, 1998, all symptoms were improved with the vanishment of swelling of shin, but occasional pain occurred at shoulder, back and chest. On Feb. 21, 1998, symptoms were improved. On Mar. 7, 1998, alternative medication was taken for function failure of heart. On Mar. 28, 1998, slight pain of the right costal region has vanished with significant improvement of abdominal swelling. FPE was decreased to 232 (+). Cancer type: hepatoma Name of subject: Mr. Chi-Chang Chen Original number of case: 97070922 Date of birth: Aug. 30, 1932 The hospital making diagnosis: Tainan Chi-Mei Address: unknown Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: January 1997 angiography Place of hospital: Tainan City, Taiwan Diagnosis: a hepatoma of 12.5 cm Main cancer-related symptoms: After hospitalization at the original hospital for Tightness and pain of the right costal region, treatment, he was referred to Kaohsiung Chang Gung abdominal swelling and swelling of shin Hospital for thrombosis procedure and treatment in Other minor symptoms: March 1997. Arrhythmia and frequent micturition during the night This subject has enrolled into this trial since Jul. 9, 1997 till Aug. 16, 1997 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jul. 22, 1997, symptoms of tightness and pain of Determination of efficiency: with efficiency the right costal region and abdominal swelling were Filed on Mar. 15, 2002 alleviated. On Aug. 2, 1997, main symptoms were significantly improved. Cancer type: hepatoma (metastasized from colon) Name of subject: Mrs. Show-Ying Chen Original number of case: 97081426 Date of birth: Aug. 20, 1948 The hospital making diagnosis: Taichung Veteran Address: N. District, Taichung General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, CT and ultrasonic scan Date of diagnosis: January 1994 and angiography Place of hospital: Taichung City, Taiwan Diagnosis: after dissection and chemotherapy, colon cancer metastasized to liver and then to ovary. Main cancer-related symptoms: After dissection cancer and chemotherapy of colon Occasional sudden pain of the right costal region and cancer at Veteran General Hospital, cancer was occasional illness of lower abdomen metastasized to liver. After ineffective chemotherapy, Other minor symptoms: cancer was metastasized to ovary. She has been Weakness treated at China Medical College Hospital and Taichung Ren-Ai Hospital. This subject has enrolled into this trial since Aug. 14, 1997 till Sep. 22, 1997 for a total of 3.5 courses and 42 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Aug. 19, 1997, main symptoms were alleviated. Determination of efficiency: with efficiency On Sep. 4, 1997, main symptoms were further Filed on Mar. 15, 2002 alleviated. Cancer type: hepatoma Name of subject: Mrs. Shu-Nv Chen Original number of case: 01061306 Date of birth: Nov. 11, 1942 The hospital making diagnosis: Taichung Veteran Address: Guosing, Nantou Hsien General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: Feb. 15, 2001 angiography Place of hospital: Taichung City, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: Thrombosis procedures were performed at the Hard swelling of the right costal region, as well as original hospital after diagnosis. right abdomen, swelling hard as stone of stomach, belch, and fever around nightfall Other minor symptoms: tiredness and fatigue, subclinical jaundice, yellowish micturition during night, and lost of appetite This subject has enrolled into this trial since Jun. 13, 2001 till Oct. 3, 2001 in a total of 10 courses and 120 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jun. 27, 2001, abdominal swelling was alleviated Determination of efficiency: with efficiency during the night. Filed on Mar. 15, 2002 On July 11, hard swelling of the right costal region has softened and dispersed. On Aug. 8, 2001, tumor of stomach has dispersed for over 1/3 and nightfall fever has vanished Cancer type: hepatoma Name of subject: Mr. Jin-Qian Chen Original number of case: 98041902 Date of birth: Mar. 22, 1959 The hospital making diagnosis: Pingtung Christian Address: Changjr, Pingtung Hsien Hospital. Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: Apr. 2, 1998 angiography Place of hospital: Pingtung Hsien, Taiwan Diagnosis: hepatoma and liver cirrhosis Main cancer-related symptoms: After confirmation of diagnosis, he was transferred to Occasional pain of the right costal region, abdominal Dunggang An-Tai hospital on April 9 for thrombosis swelling and swelling of shin procedure. Other minor symptoms: Gastric ulcer, tiredness and lack of strength, and yellow-brownish facial skin, slight swelling edema, and normal urination and excretion This subject has enrolled into this trial since Apr. 19, 1998 till Apr. 15, 1999 for total of 20 courses and 240 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 1, 1998, the main symptoms have been Determination of efficiency: significant efficiency, improved efficiency, no efficiency and undetermined On May 13, 1998, the liver tumor was dispersed as Filed on Mar. 15, 2002 seen in scan. On May 26, 1998, gastric ulcer has been amended. On Jul. 23, 1998, main symptoms were significantly alleviated or vanished. On Nov. 1, intestinal hemorrhage occurred, as well as insufficient platelet. Since Dec. 27, 1998, all symptoms have all vanished and his spirit and physical strength were better. Cancer type: hepatoma Name of subject: Mrs. Pao-Zhu Chen Original number of case: 01080801 Date of birth: Dec. 17, 1939 The hospital making diagnosis: Chunghua Christian Address: Beitou, Chunghua Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan and Date of diagnosis: March 2001 angiography Place of hospital: Chunghua Hsien, Taiwan Diagnosis: a hepatoma of 5.2 cm complicated with hepatitis C infection Main cancer-related symptoms: At the original hospital, she has been through one Hardness of stomach and left spleen, pain of the right thrombosis procedure on March 19, another on May costal and abdominal region, swelling and belching 15 and a alcohol chemotherapy on July 25. Other minor symptoms: 3 or 4 times of excretions after taking laxative, micturition of small amount with difficulty, and swelling of shin This subject has enrolled into this trial since Aug. 8, 2001 till Sep. 24, 2001 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On August 16, main symptoms were alleviated. Determination of efficiency: inefficiency On Aug. 31, 2001, due to the administration of Filed on Mar. 15, 2002 western medicines for cold and long term diarrhea, her spleen has been damaged. A hepatoma of 6.5 cm was detected via scan and the trial medication was continuously taken for 24 days. No follow-up report was available. Cancer type: hepatoma Name of subject: Mr. Guo Shiong Chen Original number of case: 99111103 Date of birth: Mar. 25, 1962 The hospital making diagnosis: Kaohsiung Ruan Address: Chianjen District, Kaohsiung City Surgical General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: March 1997 Place of hospital: Kaohsiung City, Taiwan Diagnosis: diagnosed in March 1997 by Ruan Surgical General Hospital and had a thrombosis procedure on Oct. 20, 1999 and then scanned again at Min-Sheng Hospital. Main cancer-related symptoms: A recurrence hepatoma of 3.7 cm together with Occasional pain of the right costal region and carcinoma and a previous gastric hemorrhage on abdominal swelling Oct. 20, 1999. Other minor symptoms: Yellowish normal urination, lost of appetite and 2 or 3 times of excretion in a day This subject has enrolled into this trial since Nov. 11, 1999 till Jan. 25, 2000 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On November 25, the pain of the right costal region Determination of efficiency: significant efficiency has alleviated and the swelling of stomach has Filed on Mar. 15, 2002 vanished. On December 2, the pain of the right costal region and the swelling of stomach have vanished. The scan performed on January 13 of 2000 has shown that the recurred tumor mass of 3.7 cm has significant reduced with no sign of tumor cells. Cancer type: intrahepatic bile duct cancer Name of subject: Mr. Ming-Zhu Zhuang Original number of case: 99040216 Date of birth: Mar. 2, 1935 The hospital making diagnosis: Kaohsiung Veteran Address: Tzuoying District, Kaohsiung City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Apr. 1, 1999 Place of hospital: Ksohsiung City, Taiwan Diagnosis: a total of 3 intrahepatic bile duct tumor with a big one of 3.4 cm Main cancer-related symptoms: After direct enrollment into this trial, his condition Complaints of heart and the right costal areas and has improved after 3 courses. However, some of his swelling of stomach (hypertrophy of veins) family has disobeyed the trial regulation to refer him Other minor symptoms: to thrombosis procedures. Headache, facial edema, tiredness and fatigue, micturition of small amounts, skin itchiness and impotence of heart This subject has enrolled into this trial since Apr. 2, Before trial, his AFP value was 38.9 with a liver 1999 till Jul. 7, 1999. tumor of 3.4 cm. Trial procedure: On May 4 (after 2 courses), his AFP has dropped to The medication combination, specific for treating 26.6 and the size of tumor has shrunken to 2.7 cm. hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Apr. 15, 1999, main symptoms have alleviated Determination of efficiency: with efficiency with a slow heartbeat. Filed on Mar. 15, 2002 On Apr. 27, 1999, main symptoms have vanished with a better facial color and vitality. The trial medication was continuously taken after May 1, 1999, although a thrombosis procedure was performed (which was known thereafter) which was unrelated to this trial. Cancer type: hepatoma Name of subject: Mr. Shu-Shun Zhuang Original number of case: 97112112 Date of birth: 1938 The hospital making diagnosis: Pingtung Christian Address: Yanpu, Pingtung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: October 1997 Place of hospital: Pingtung Hsien, Taiwan Diagnosis: hepatoma and liver cirrhosis Main cancer-related symptoms: Directly enrolled into this trial Pain of the right costal region and swelling of stomach Other minor symptoms: Tiredness and fatigue, yellowish micturition of small amounts This subject has enrolled into this trial since In February, 1999, the main symptoms occasionally Nov. 21, 1997 till Sep. 5, 1998 for a total occurred, which have vanished after a further 3 of 14 courses and 168 days. courses of treatments. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On December 3, main symptoms were significantly Determination of efficiency: significant efficiency alleviated. Filed on Mar. 15, 2002 On December 17, symptoms were further improved and the pain of the right costal region has vanished. On Jan. 1, 1998, main symptoms have vanished without any recurrence before the end of trial. Cancer type: hepatoma Name of subject: Mrs. Ying Shu Original number of case: 01061501 Date of birth: 1939 The hospital making diagnosis: Kaohsiung Chang Address: Daliau, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy, CT and ultrasonic scan Date of diagnosis: June, 1998 and angiography Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: hepatoma, liver cirrhosis and hepatitis C infection Main cancer-related symptoms: After confirmation of diagnosis, serial alcohol Pain of the right costal region, abdominal swelling, chemotherapies were performed at the original difficulty in excretion and urination, swelling of shin hospital, together with 4 thrombosis procedures. and bleeding of gums However, the condition was not improved. Other minor symptoms: Darken facial color, tiredness and fatigue, weakness of the upper eyelids, high fever during the night This subject has enrolled into this trial since Jun. 15, 2001 till Oct. 11, 2001 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jul. 10, 2001, during the 2^(nd) course, main Determination of efficiency: with efficiency symptoms have significantly improved, so did the Filed on Mar. 15, 2002 minor symptoms. However, due to the family matters, mediation was stopped for 45 days. On Sep. 11, 2001, pain of the right costal region has vanished, urination difficulty and shin swelling have improved, and however, abdominal swelling and excretion difficulty was not changed. Till the end of treatment, pain of the right costal region did not recur and main symptoms were improved, however, his vitality and physical strength were not significantly improved. Cancer type: hepatoma Name of subject: Mr. Yi-Wan Chang Original number of case: 01040402 Date of birth: May 19, 1940 The hospital making diagnosis: Cheng Kung Address: Chigu, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: nuclear examination and CT and Date of diagnosis: Apr. 9, 2001 ultrasonic scan Place of hospital: Tainan City, Taiwan Diagnosis: a hepatoma of 3.0 cm, liver cirrhosis and diabetes Main cancer-related symptoms: After confirmation of diagnosis at Cheng Kung Stuffy pain of the right costal region, abdominal University Hospital, he was hospitalized at Chi-Mei swelling and swelling of shin Hospital and has taken folk prescriptions, which Other minor symptoms: resulted in his diarrhea. Sleepless, micturition of small amounts, skin itchiness, 6 or 7 times of excretion in a day and diarrhea This subject has enrolled into this trial since Apr. 28, 2001 till Aug. 9, 2001 for a total of 8 courses and 96 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. During the 1^(st) and 2^(nd) courses, main symptoms have Determination of efficiency: inefficiency significantly improved, however, after June 9, the Filed on Mar. 15, 2002 condition was fluctuant and unstable. One Jul. 21, 2001, via the examination at Taiwan University Hospital, cancer metastasis was found on both sides of liver, therefore, this case was classified as not efficient. Cancer type: hepatoma Name of subject: Mr. Wen-Tai Zeng Original number of case: 97060738 Date of birth: 1954 The hospital making diagnosis: Kaohsiung Medical Address: Gangshan, Kaohsiung Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Sep. 15, 2000 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: 3 hepatoma masses and liver cirrhosis Main cancer-related symptoms: On October 25, after the 1^(st) course of treatment, Pain of the right costal region and abdominal swelling thrombosis procedure was performed at Kaohsiung Other minor symptoms: Medical University Hospital. Sleepless, tiredness and fatigue, difficulty of urination, spontaneous sweating, sprain of limbs and 3 times of excretion in a day. This subject has enrolled into this trial since On Apr. 3, 2001, after the re-disappearance of main Sep. 16, 2000 till Oct. 26, 2001. symptoms, trial medication was taken on and off till Trial procedure: the end of trial and main symptoms did not recur. The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. During the 1^(st) course, symptoms were alleviated, Determination of efficiency: with efficiency however, after a thrombosis procedure at Kaohsiung Filed on Mar. 15, 2002 Medical University Hospital on October 25; the condition was deteriorated and not improved by medication or chemotherapy. On November 23, medication for an half course was given. He was back to this trial on Mar. 22, 2001. Cancer type: hepatoma Name of subject: Mr. Guo-Ke Zeng Original number of case: 97071602 Date of birth: Sep. 3, 1928 The hospital making diagnosis: Pingtung Ren-Ai Address: Shinbei, Pingtung Hsien Hospital Hospital grade: general (the 3^(rd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: March 1997 Place of hospital: Pingtung Hsien, Taiwan Diagnosis: hepatoma and recurrence after chemotherapy Main cancer-related symptoms: After confirmative diagnosis at Kaohsiung Chang Abdominal swelling and occasional pain around the Gung Hospital in 1995, unknown treatment was navel given. In March 1997, after scanning at Ren-Ai Other minor symptoms: Hospital, chemotherapy was performed but the Tiredness and fatigue, lost of appetite, and difficulty condition deteriorated with abdominal swelling and a in excretion AFP of 350. This subject has enrolled into this trial since Jul. 16, Symptoms, including vomiting, belching and 1997 till Sep. 2, 1998 for a total of 28 courses accidiental erysipelas, were cured with administration and 336 days. of this trial medication, sometime supplemented with Trial procedure: alternative drugs. Till the end of this trial, hepatic The medication combination, specific for treating function was normal with no recurrence of abdominal hepatoma and pancreatic cancer, is taken within 90 swelling. minutes after meals, that is 3 times a day for a total of 12 gm. On Aug. 13, 1997, during the 2^(nd) course, man Determination of efficiency: significant efficiency symptoms were significantly alleviated and minor Filed on Mar. 15, 2002 symptoms were nearly disappeared. During the 4^(th) course, all symptoms were disappeared. Based on the recurrence of symptoms after the last chemotherapy, the trial medication was continuously taken with occasional abdominal swelling. Cancer type: hepatoma Name of subject: Mrs. Jia-He Zeng Original number of case: 98120104 Date of birth: Jan. 5, 1940 The hospital making diagnosis: Linko Chang Gung Address: Shinpu, Hsinchu Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: November 1998 Place of hospital: Taipei Hsien, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: After confirmative diagnosis, thrombosis procedure Stomach pain with 2 masses, hard as stone, and pain was performed and health food, Ginseng powder, was at one side of abdomen taken (which was known afterwards) Other minor symptoms: Bitterness and thirst of mouth, lost of appetite, 3 or 4 times of excretion in a day and difficulty of urination This subject has enrolled into this trial since Dec. 1, 1998 till Jan. 13, 1999 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Dec. 16, 1999, during the first course, the Determination of efficiency: with efficiency tumor mass has dispersed for 1/3 and his vitality and Filed on Mar. 15, 2002 strength has been improved. On Jan. 1, 1999, he violated the contradiction by taking food that increased blood pressure of the portal vein and therefore, resulted in an extreme abdominal swelling, which was unrelated to this trial medication. Cancer type: hepatoma with metastasis Name of subject: Mr. Rui-Feng Ye Original number of case: 98111206 Date of birth: Aug. 20, 1957 The hospital making diagnosis: Kaohsiung Ruan Address: Chijin District, Kaohsiung City Surgical General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: September 1998 Place of hospital: Kaohsiung City, Taiwan Diagnosis: hepatoma, liver cirrhosis, higher hepatic index, a blood sugar AC of 152 and Gout Main cancer-related symptoms: After hospitalization at the original hospital, his Stomach swelling, pain of the right costal region and condition continuously deteriorated with a hepatic stuffiness of chest index higher than normal. Other minor symptoms: Darken facial skin, skinny, tiredness and fatigue, yellowish micturition of small amounts and swelling of shin This subject has enrolled into this trial since During the examination at Ruan Surgical General Nov. 12, 1998 till Nov. 6, 1999 for a total Hospital on March 9, the metastasized site was of 16 courses and 192 days. calcified and the original tumor was under control. Trial procedure: During the follow-up at Ruan Surgical General The medication combination, specific for treating Hospital in August 1999, intrahepatic spot was hepatoma and pancreatic cancer, is taken within 90 detected but without any sign of cancer cells via minutes after meals, that is 3 times a day for a total of biopsy. Digestive tracts were normal as checked by 12 gm. laparoscopy. On Nov. 24, 1998, all symptoms were alleviated Determination of efficiency: significant efficiency but feet tendons were occasionally suffered from Filed on Mar. 15, 2002 sprain. On Dec. 26, 1998, symptoms were further alleviated but with gout at feet. On Jan. 9, 1999, all symptoms were nearly vanished, together with normal hepatic index and vanishment of complication. Cancer type: hepatoma Name of subject: Mr. Tian-Cai Huang Original number of case: 97030402 Date of birth: Sep. 22, 1929 The hospital making diagnosis: Cheng Kung Address: Lioujia, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Feb. 20, 1997 Place of hospital: Tainan City, Taiwan Diagnosis: hepatoma with metastasis to lung Main cancer-related symptoms: Peaceful managements, such as anesthesia and pain Pain at the lower right costal region and abdominal killing, were adopted by the original hospital. swelling Other minor symptoms: Tiredness and fatigue, excretion difficulty, micturition, weakness and movement difficulty This subject has enrolled into this trial since Mar. 4, 1997 till May 6, 1997 for a total of 4.5 courses and 54 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 15, 1997, symptoms were significantly Determination of efficiency: significantly efficiency alleviated and able to walk independently to Activity Filed on Mar. 15, 2002 Center of Senior. Since he was asked to stop medication for anesthesia, he has experienced palpitation, vomiting and yawning in the first 3 or 4 days. On Mar. 29, 1997, pain of the lower right costal region has vanished, so did the abdominal swelling, without any recurrence Cancer type: hepatoma Name of subject: Mrs. Mei-Huei Huang Original number of case: 98012708 Date of birth: Sep. 8, 1951 The hospital making diagnosis: Pingtung Christian Address: Yanpu, Pingtung Hsien Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: December 1997 Place of hospital: Pingtung Hsien, Taiwan Diagnosis: a hepatic angioma of 5.0 cm Main cancer-related symptoms: Folk prescriptions with a nature of cold have been Pain of the right costal region and no hungry feeling taken which were harmful for spleen and therefore led of stomach to diarrhea. Other minor symptoms: tiredness and fatigue, yellowish-pale facial skin, dryness and bitterness of mouth, sleepless, unsolidified stool and micturition This subject has enrolled into this trial since Jan. 24, 1998 till Aug. 5, 1998 for a total of 11.5 courses and 138 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 13, 1998, symptoms were alleviated. Determination of efficiency: significant efficiency On Feb. 26, 1998, symptoms have vanished Filed on Mar. 15, 2002 except the occasional pain of the right costal region. On Mar. 18, 1998, via a scan at the original hospital, intrahepatic tumor has shrunken. No symptoms recurred before the end of trial. The patient's vitality and strength were as normal and able to work at the beginning of April (he was a building worker) Cancer type: hepatoma Name of subject: Mrs. Qiu-Yue Huang Original number of case: 01011409 Date of birth: Sep. 14, 1935 The hospital making diagnosis: Chi-Mei Hospital, Address: Shinshing District, Kaohsiung City Tainan Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: July 2000 Place of hospital: Tainan City, Taiwan Diagnosis: 5 tumor mass of hepatoma Main cancer-related symptoms: After confirmative diagnosis at Chi-Mei Hospital in Pain of the right costal region, sharp pain from right July, 2000, thrombosis procedure was performed right waist, hip to foot, abdominal pain and swelling, after. She was transferred to Ruan Surgical General urination difficulty, and swelling of shin Hospital in August for a treatment of 14 days. After Other minor symptoms: discharged from the hospital, she has taken Chinese Weakness, movement difficulty, lost of appetite, medicines, which led to deterioration and swelling. sleepless and constipation with twice excretions a She was admitted into Ruan Surgical General day. Hospital again to treatment till Jan. 17, 2001. This subject has enrolled into this trial since Jan. 14, 2001 till February 26 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jan. 31, 2001, during the treatment course, Determination of efficiency: undetermined swelling was gradually dispersed and pain of the right Filed on Mar. 15, 2002 costal region reduced, however, due to the eagerness of family and unbearable sharp pain from right waist, hip to foot, she still went back to Ruan Surgical General Hospital for anesthesia treatment during the treatment course. Therefore, the trial medication could not exert the full effect. Cancer type: liver carcinoma Name of subject: Mr. Wu-Shiong Huang Original number of case: 99080108 Date of birth: Nov. 29, 1939 The hospital making diagnosis: Kaohsiung Medical Address: Fengshan, Kaohsiung Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: March 1994 Place of hospital: Kaohsiung City, Taiwan Diagnosis: liver carcinoma complicated with hepatitis B, hepatitis C, uremia, diabetes and hypertension Main cancer-related symptoms: Alcohol chemotherapy or thrombosis procedure was Stuffiness of chest with sputum, abdominal swelling performed at Kaohsiung Medical University Hospital and occasional pain of the right costal region in 1994. However, after less than 90 days, another Other minor symptoms: tumor recurred and complicated with other Lost of appetite, usual constipation, micturition, conditions, such as uremia (tumor size about 1.0 cm). swelling of shin, sleepless, waist ache and dizziness This subject has enrolled into this trial since Aug. 1, 1999 till Apr. 21, 2001 for a total of 44 courses and 528 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. After long-term thrombosis procedure, patient's Determination of efficiency: with efficiency condition was unique and complicated. However, Filed on Mar. 15, 2002 main symptoms were partially alleviated and AFP was stably maintained, which could support the efficiency of this trial medication on hepatoma. Furthermore, new tumor mass appeared at less than 90 days after the previous thrombosis procedure. However, another new tumor mass was found as late as Nov. 5, 2000, which was as far as 450 days after Aug. 1, 1999, the date of starting the trial. This could further support the efficiency on this case. Cancer type: hepatoma Name of subject: Mr. Jin-Fu Huang Original number of case: 97083102 Date of birth: Feb. 20, 1932 The hospital making diagnosis: Ksohsiung Chang Address: Chaujou, Pingtung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: Aug. 14, 1997 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: malignant multiple hepatoma, complicated with diabetes and hepatitis B. Main cancer-related symptoms: Unknown Sharp and sudden pain of the right costal region, and abdominal swelling Other minor symptoms: excretion difficulty, reddish micturition, tiredness and fatigue, sleepiness, thirst and high fever This subject has enrolled into this trial since Aug. 31, 1997 till Nov. 6, 1997 for a total of 5 courses and 60 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 12, 1997, during the 1^(st) course, main Determination of efficiency: inefficiency symptoms were significantly alleviated. Thereafter, Filed on Mar. 15, 2002 he admitted into Tian-Suen Hospital due to the high fever and ache. After administration of this medication, his vitality and appetite were better and therefore continued for 1 course. In following, he has taken another 2 courses with no further improvement. Cancer type: hepatoma Name of subject: Mr. Ching-Ke Huang Original number of case: 97082002 Date of birth: Oct. 26, 1935 The hospital making diagnosis: Ksohsiung Chang Address: Yanshuei, Tainan Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: May 1997 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: a hepatoma mass of 5.0 cm, liver cirrhosis, hepatitis B carrier and complications of coughing and gasping (bronchitis) Main cancer-related symptoms: Unknown and a hepatoma of 6.0 cm was scanned at Pain of the lower edge of right costal region and Wang Kuo Chin Clinical in August 1997. occasional chest pain Other minor symptoms: tiredness and fatigue, night cough and gasp, sleepless, sweating, and micurition This subject has enrolled into this trial since Aug. 20, 1997 till Jan. 10, 1998 for a total of 12 courses and 144 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Aug. 31, 1997, pain of the lower edge of right Determination of efficiency: with efficiency costal region and chest pain have alleviated. Filed on Mar. 15, 2002 On Sep. 26, 1999, main symptoms have vanished. Although minor symptoms, such as gasping and coughing, were not relieved, none main symptoms recurred before the end of trial. Even the occasional pain happened which could be relieved right after the administration of the trial medication. Cancer type: hepatoma Name of subject: Mrs. Shu-Yuan Huang Original number of case: 99042312 Date of birth: Oct. 21, 1935 The hospital making diagnosis: Chiai St. Martin Address: Shiluo, Yunlin Hsien Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: April. 1999 Place of hospital: Chiai Hsien, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: Chemotherapy performed at the original hospital Pain of the right chest and costal region and swelling and occasional pain of abdomen Other minor symptoms: 6 to 8 times of unsolidified stool, small amount of urination and cough This subject has enrolled into this trial since Apr. 23, 1999 till Jul. 23, 1999 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 2, 1999, man symptoms were significantly Determination of efficiency: with efficiency alleviated and the minor symptoms were slightly Filed on Mar. 15, 2002 improved. On Jun. 12, 1999, main symptoms recurred but not as serious as previous. Till the end of trial, main symptoms were continuously improved. Cancer type: pancreatic adenocarcinoma Name of subject: Mrs. Ye Ge Chiu Huang Original number of case: 01011215 Date of birth: Sep. 10, 1911 The hospital making diagnosis: Kaohsiung Address: Chianjin District, Kaohsiung City Ming-Sheng Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: nuclear examination and CT and Date of diagnosis: January 2001 ultrasonic scan Place of hospital: Kaohsiung City, Taiwan Diagnosis: pancreatic adenocarcinoma, CA19-9: 17200, CA72-4: 7.70 Main cancer-related symptoms: abdominal swelling Since the patient was old, alternative therapies, and pain, pain of the right costal region, and pain of including diuretics and laxatives, were temporarily inner side of the left leg with movement difficulty given by the hospital. Other minor symptoms: Abnormal excretion and urination, lost of appetite, and occasional trace blood or lump in stool This subject has enrolled into this trial since Jan. 21, 2001 till May 22, 2001 for a total of 6 courses and 72 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 15, 2001, stomach pain was significantly Determination of efficiency: with efficiency alleviated, able to walk and urination amounts Filed on Mar. 15, 2002 increased. On Mar. 7, 2001, stomach pain was further alleviated; pain of the right costal region reduced and pain of legs has vanished. The administration of trial medication was often discontinued due to certain reasons. During the trial period, main symptoms were continuously alleviated with the administration of medication. Cancer type: hepatoma Name of subject: Mr. Shui-Yuan Yang Original number of case: 01101201 Date of birth: Sep. 8, 1941 The hospital making diagnosis: Kaohsiung Chang Address: Fengshan, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: November 2000 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: a hepatoma of 2.4 cm, and pancreatic abnormality with a CA 19-9 of 57.02 and a higher hepatic index Main cancer-related symptoms: After confirmation of diagnosis, alcohol Abdominal swelling, occasional pain of the right chemotherapies were performed in the original costal region, swelling of shin and occasional pain at hospital on and off till October 2001. navel. Other minor symptoms: Tiredness and fatigue, dryness and bitterness of mouth, urination difficulty, and occasional bleeding of veins in stomach This subject has enrolled into this trial since Oct. 12, 2001 till Dec. 6, 2001 for a total of 5 courses and 60 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Oct. 24, 2001, abdominal swelling and pain of Determination of efficiency: significant efficiency the right costal region have vanished and swelling has Filed on Mar. 15, 2002 alleviated. On Nov. 4, 2001, all symptoms were further alleviated with a reduction of hepatic index. At the end of treatment, main symptoms were significantly alleviated with the vanishment of swelling and the shrunken of tumor mass from 2.4 cm to 1.6 cm. Cancer type: hepatoma Name of subject: Mrs. Liu Zhi Ying Zhan Original number of case: 97050102 Date of birth: Jun. 6, 1919 The hospital making diagnosis: Taichung Veteran Address: S. District, Tainan City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: April 1997 Place of hospital: Taichung City, Taiwan Diagnosis: a hepatoma of 12.0 cm with an AFP of 268 and a higher hepatic index Main cancer-related symptoms: Due to senility, she was not willing to be through Pain of the right costal region, abdominal swelling, procedures of dissection, thrombosis or hunger without the desire to eat and yellowish chemotherapy. Therefore she directly participated this urination trial. Other minor symptoms: Tiredness and fatigue, insufficient strength, movement difficulty and lost of appetite This subject has enrolled into this trial since May 1, 1997 till Feb. 27, 1998 for a total of 12 courses and 144 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 31, 1997, pain of the right costal region was Determination of efficiency: significant efficiency alleviated. Filed on Mar. 15, 2002 On Jun. 21, 1997, pain of the right costal region has vanished; abdominal swelling and appetite have improved. On Aug. 26, 1997, after examination of Taichung Veteran General Hospital, hepatoma has been found to shrink with a normal AFP and she was able to help with the housework. Cancer type: intrahepatic bile duct cancer Name of subject: Mrs. Shi Mei yu Ge Original number of case: 97110826 Date of birth: Jun. 15, 1922 The hospital making diagnosis: Taipei Veteran Address: Hsinchu, City, Hsinchu Hsien General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: October 1997 Place of hospital: Taipei City, Taiwan Diagnosis: intrahepatic bile duct cancer with a higher hepatic index Main cancer-related symptoms: Unknown Pain and swelling of the right costal region, abdominal swelling, jaundice and vomit Other minor symptoms: Weakness, insufficient strength, and accustomed constipation This subject has enrolled into this trial since Nov. 8, 1997 till Mar. 4, 1998 for a total of 9 courses and 108 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Nov. 25, 1997, main symptoms were Determination of efficiency: with efficiency alleviated but still vomiting during taking the Filed on Mar. 15, 2002 medication. Appetite was improved. On Dec. 19, 1997, the vomit was stopped with better appetite and vitality, however, still with constipation. At the end of treatment, main symptoms were significantly alleviated and physical strength was gradually recovered. Cancer type: pancreatic adenocarcinoma Name of subject: Mr. Wei-Ren Cheng Original number of case: 00062311 Date of birth: Oct. 25, 1966 The hospital making diagnosis: Linko Chang Gung Address: Tsztung, Yunlin Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: Date of diagnosis: December 1999 Place of hospital: Taipei Hsien, Taiwan Diagnosis: pancreatic adenocarcinoma Main cancer-related symptoms: He was treated for diabetes at Chunghua Christian Vomiting mucus at 1 hour after breakfast, abdominal Hospital during 1996. Via scan at Chiai Christian swelling, diarrhea of 5 or 6 times in a day Hospital and Zhushan Showchuan Hospital, Other minor symptoms: unidentified objective was found. After angiography Tiredness and fatigue, gasping and emaciation performed at Shalu Guang Tain Hospital, pancreatic adenocarcinoma was confirmed by Linko Chang Gung Hospital. This subject has enrolled into this trial since Jun. 23, 2000 till Aug. 5, 2000 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. From Jun. 6, 2000, the beginning of this trial till the Determination of efficiency: inefficiency end of treatment, condition was merely maintained Filed on Mar. 15, 2002 without deterioration. Main symptoms, vitality, and physical strength were not improved. Cancer type: hepatoma Name of subject: Mr. Jian Chuan Su Original number of case: 01030406 Date of birth: Oct. 1, 1947 The hospital making diagnosis: Linko Chang Gung Address: Gueishan, Taoyuan Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: February 2000 Place of hospital: Taipei Hsien, Taiwan Diagnosis: a small hepatoma was detected in February 2000. After chemotherapy and examined again in February, 2001, a hepatoma of 0.6 cm was detected. Main cancer-related symptoms: On Feb. 21, 2001, CEA was 7.83, AFP was Occasional sudden pain and tightness of the right 16.34, CA19-9 was 55.51 and hepatic indexes were costal region, abdominal stuffiness and heartburn too high. Other minor symptoms: Tiredness and fatigue, excretion of twice a day, and sleepiness This subject has enrolled into this trial since Mar. 4, 2001 till Mar. 10, 2002 for a total of 28 courses and 346 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Mar. 20, 2001, main symptoms was alleviated Determination of efficiency: with efficiency and, during the following courses, main symptoms Filed on Mar. 15, 2002 vasinshed or occasionally occurred but slightly. On Apr. 7, 2001, CEA was 7.1, AFP was 16.25, CA19-9 51.20 and hepatic index was reduced. On Jun. 1, 2001, CEA was 12.3, AFP was 15.23, CA19-9 was 54.9 and hepatic index was slightly elevated. On Sep. 21, 2001, CEA was 7.30, AFP was 12.66, and CA19-9 was 52.9. On Jan. 17, 2002, CEA was 6.0, AFP was 14.25 and CA19-9 was 21.9. Cancer type: hepatoma Name of subject: Mrs. Chang Yue Li Zheng Original number of case: 00052501 Date of birth: Sep. 1, 1929 The hospital making diagnosis: Gangshan Weishan Address: Hunei, Kaohsiung Hsien General Hospital Hospital grade: general (the 3^(rd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: May 3, 2000 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: 2 hepatomas of 4.0 cm and 1.0 cm, with lipidemia and a ALT/AST over 60 Main cancer-related symptoms: After the medication of the original hospital with no Tightness of the right costal region, abdominal efficiency, main symptoms were not improved, she swelling and acid retching participated this trial. Other minor symptoms: Sleepless, dizziness, constipation firstly and then diarrhea twice a day. This subject has enrolled into this trial since May 25, 2000 till Aug. 31, 2000 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Jul. 11, 2000, main symptoms were alleviated. Determination of efficiency: significant efficiency On Aug. 3, 2000, the hepatoma has shrunken from Filed on Mar. 15, 2002 4.0 cm to 2.0 cm and another hepatoma of 1.0 cm has vanished. Hepatic indexes and neutral fatty acid were normal. Cancer type: hepatoma Name of subject: Mr. Ming Ho Liu Original number of case: 97090702 Date of birth: Oct. 27, 1931 The hospital making diagnosis: National Cheng Gung Address: Yanshuei, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: December 1994 Place of hospital: Tainan City, Taiwan Diagnosis: a hepatoma of 2.0 cm, which was deteriorated via the diagnosis of Kaohsiung Chang Gung Hospital in January 1997 Main cancer-related symptoms: Unknown, complicated with liver cirrhosis, diabetes, Pain of the right lower costal region, diarrhea with hypersensitivity of prostate more than 10 times in a day, back pain and ache and vomiting Other minor symptoms: Micturition of small amount, sleepless, tiredness and fatigue, weakness and insufficient strength, thirst and gasping This subject has enrolled into this trial since Sep. 7, 1997 till Dec. 25, 1997 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. In the initial stage of treatment, the condition was Determination of efficiency: inefficiency merely maintained without deterioration. At the end Filed on Mar. 15, 1992 of treatment, main symptoms, vitality and physical strength were not improved at all. Cancer type: hepatoma Name of subject: Mr. Shing Yun Liu Original number of case: 99031012 Date of birth: Apr. 4, 1943 The hospital making diagnosis: Taipei Veteran Address: Shinfeng, Hsinchu Hsien General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: Aug. 12, 1998 Place of hospital: Taipei Hsien, Taiwan Diagnosis: hepatoma and liver cirrhosis Main cancer-related symptoms: Surgery was performed at Taipei Veteran General Pain of the left and right costal region, abdominal Hospital in 1998 followed by chemotherapy with a swelling and hard as stone, occasionally sharp pain of normal AFP. At 120 days after, AFP was elevated the waist and abdomen and numbness of limbs again and tumor has metastasized into the spinal bone Other minor symptoms: of waist and hip. Micturition of small amount, and sleepless This subject has enrolled into this trial since Mar. 10, 1999 till Jul. 20, 1999 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. After 2 courses of treatment, main symptoms were Determination of efficiency: inefficiency alleviated and the catheter for chemotherapy was Filed on Mar. 15, 2002 removed. However, during the following courses, main symptoms recurred with no efficiency Cancer type: hepatoma Name of subject: Mr. Yu-Lai Lai Original number of case: 99101304 Date of birth: Nov. 8, 1942 The hospital making diagnosis: Linko Chang Gung Address: Zhuolan, Miaoli Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: June 1999 Place of hospital: Taipei Hsien, Taiwan Diagnosis: multiple hepatoma with a radical pattern and the big one is of 5.6 cm Main cancer-related symptoms: After hospitalization at Linko Chang Gung Hospital, Tightness of the right costal region, abdominal in June 1999, he has taken Chinese medicine. On swelling with occasional pain and vomiting, small Oct. 2, 1999, the first thrombosis procedure was amount of urination performed in Taichung Ton General Hospital. After Other minor symptoms: entering this trial, on January 5, the second Diarrhea of 5 or 6 times in a day, tiredness and thrombosis procedure was performed in Ton Surgical dizziness Hospital, and also decided to stay on this trial (blood vomiting occurred after the thrombosis procedure). This subject has enrolled into this trial since Oct. 13, 1999 till Apr. 5, 2000 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. During the first course, main symptoms were Determination of efficiency: significant efficiency alleviated and further improved during the second Filed on Mar. 15, 2002 course. On Jan. 5, 2000, via the scan before the 2^(nd) thrombosis procedure, the original cancer of 5.6 cm has vanished. On Mar. 1, 2000, this trial was resumed. From the scan at Taichung Ton General Hospital, cancer mass was merely a spot, eventually disappeared with an excellent condition. Note: although the tumor mass has disappeared, before the surrounding pathology has eliminated, it was not cured. Cancer type: hepatoma Name of subject: Mr. Ming-Jie Tsai Original number of case: 00072201 Date of birth: Jan. 4, 1935 The hospital making diagnosis: Kaohsiung Veteran Address: Chijin District, Kaohsiung City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Jul. 20, 2000 Place of hospital: Kaohsiung City, Taiwan Diagnosis: a hepatoma of 7.8 cm Main cancer-related symptoms: After a scan examination on Jul. 19, 2000, at Chung Jaundice with yellowish facial and body, abdominal Gung Hospital, he transferred to Veteran General swelling or pain and ache of waist and hip Hospital on July 20 and the diagnosis was Other minor symptoms: reconfirmed. Doctors told the family that surgery was Accustomed constipation, red-brownish urination, applicable for tumor smaller than 5 cm and he was and lost of appetite not suitable for operation. Therefore, he asked to join this trial. The bile catheter was implanted on July 24 at Veteran General Hospital. This subject has enrolled into this trial since Jul. 22, 2000 till Sep. 27, 2000 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. During the 2^(nd) course, jaundice has been greatly Determination of efficiency: with efficiency reduced and pain has vanished with a reduced hepatic Filed on Mar. 15, 2002 index. The catheter was removed. Critical condition of hepatoma was surly relieved. Following treatment after the end of trial was unknown. Cancer type: hepatoma Name of subject: Mr. Zhen Fu Tsai Original number of case: 99091104 Date of birth: Feb. 15, 1946 The hospital making diagnosis: Linko Chang Gung Address: Jungli City, Taoyuan Hsien Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Sep. 7, 1999 Place of hospital: Taipei Hsien, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: Internal medication or other treatment of short term Abdominal swelling and stuffiness of the right costal without any thrombosis or chemotherapy. region Other minor symptoms: Facial spots of while sediment, and normal urination and excretion This subject has enrolled into this trial since Sep. 11, 1999 till Oct. 26, 1999 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On September 23, during the 1^(st) course, main Determination of efficiency: significant efficiency symptoms were eliminated without any recurrence Filed on Mar. 15, 2002 after another 2 courses Cancer type: hepatoma Name of subject: Mr. Chian-Ming Tsai Original number of case: 98082202 Date of birth: Feb. 9, 1948 The hospital making diagnosis: Kaohsiung Chang Address: Nantz District, Ksohsiung City Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: April 1998 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: hepatoma Main cancer-related symptoms: A thrombosis procedure was performed on Apr. 30, Occasional pain of the right costal region 1998 at Chung Gung Hospital and others were Other minor symptoms: unknown. Tiredness and fatigue, gasping, sleepless, spontaneous sweating, spermatorrhea, skin itchiness and irritation This subject has enrolled into this trial since Aug. 22, 1998 till Dec. 22, 1998 for a total of 5.5 courses and 66 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Sep. 3, 1998, during the 1 ^(st) course, pain of Determination of efficiency: significant efficiency the right costal region was alleviated and irritation Filed on Mar. 15, 2002 was amended. On Sep. 19, 1998, pain of the right costal region has vanished and minor symptoms were alleviated. Till Dec. 16, 1999, main symptoms were not recurred and minor symptoms were improved. Cancer type: hepatoma Name of subject: Mr. Wen-Kui Hsien Original number of case: 97032026 Date of birth: Sep. 24, 1953 The hospital making diagnosis: Kaohsiung Chang Address: Shigang, Tainan Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: November, 1996 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: a hepatoma of 13.0 cm with a higher hepatic index and a higher AFP Main cancer-related symptoms: Thrombosis procedures performed at Chang Gung Pain of the lower right costal region, swelling and Hospital hardness of the left costal region, and abdominal swelling Other minor symptoms: Sciatica of the right leg, cough, diarrhea, spontaneous sweating and night sweat This subject has enrolled into this trial since Mar. 20, 1997 till Jul. 26, 1997 for a total of 9 courses and 108 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. Main symptoms were alleviated at the initial stage Determination of efficiency: inefficiency with an elimination of sciatica of the right leg. Not Filed on Mar. 15, 2002 much improvement was achieved in the following treatment. Apart from the disappearance of pain of the lower right costal region, the left costal region was still swelling with the deterioration of sciatica of the right leg (may due to the cancer metastasis). Not much improvement for the digestive system. The patient returned to Chang Gung for electrical treatment of the leg. The case was classified as not efficient. Cancer type: intrahepatic bile duct cancer Name of subject: Mr. Chian-Lai Zhong Original number of case: 99071701 Date of birth: Jun. 28, 1936 The hospital making diagnosis: Kaohsiung Medical Address: Dashu, Kaohsiung Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: Jun. 28, 1999 Place of hospital: Kaohsiung City, Taiwan Diagnosis: intrahepatic bile duct cancer with hepatitis C Main cancer-related symptoms: Chemotherapy at the original hospital Pain of lower right costal region, chest stuffiness, abdominal swelling, and swelling of shin Other minor symptoms: High fever, tiredness and fatigue, insufficient strength, loss of appetite, micturition and excretion difficulty This subject has enrolled into this trial since Jul. 17, 1999 till Sep. 4, 1999 for a total of 4 courses and 48 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. High fever was eliminated on Jul. 21, 1999 and on Determination of efficiency: with efficiency Jul. 29, 1999, pain of the costal region was reduced Filed on Mar. 15, 2002 with improved appetite and swelling. On Aug. 14, 1999, main symptoms were alleviated with reduction in swelling but occasional acid retching. At the end of treatment, main symptoms were disappeared or significantly improved and minor symptoms were also significantly improved. Cancer type: hepatoma Name of subject: Mr. Sin-Ji Yan Original number of case: 98020602 Date of birth: Jun. 11, 1923 The hospital making diagnosis: National Chang Kung Address: Lioujia, Tainan Hsien University Hospital Hospital grade: teaching (the 1^(st) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: February 1998 Place of hospital: Tainan City, Taiwan Diagnosis: a hepatoma of 7.5 cm, hepatitis B carrier, and hepatitis C carrier Main cancer-related symptoms: After the confirmation of diagnosis, he joined this Ache of the right neck and bone joint, chest stuffiness trial with efficiency. After unknown treatment, he and excretion right after meal resumed this treatment on Aug. 18, 1998. The Other minor symptoms: tumor size in March 1998 was 6.5 cm via scan at Dizziness and lost of appetite Chang Gung and was 9.0 cm in July 1998 via scan at National Chang Kung University Hospital This subject has enrolled into this trial since Feb. 6, 1998 till Oct. 23, 1998 for a total of 7 courses and 84 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Feb. 12, 1998, main symptoms were Determination of efficiency: inefficiency improved and the diarrhea was recovered. Filed on Mar. 15, 2002 On Mar. 4, 1998, main symptoms were alleviated or recovered. Although the efficient was significant, this case did not fulfill the requirement due to the short period of trial. On Aug. 18, 1998, after the additional 5 courses, main symptoms were not improved, as well as the vitality and strength, especially the excretion right after meal. Cancer type: hepatoma Name of subject: Mrs. Yu-Chian Su Original number of case: 01086401 Date of birth: May 2, 1934 The hospital making diagnosis: Taipei Veteran Address: Chungshan District, Taipei City General Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: CT and ultrasonic scan Date of diagnosis: June 1999 Place of hospital: Taipei Hsien, Taiwan Diagnosis: hepatoma, liver cirrhosis, vesicles in pancreas and kidney hypofunction Main cancer-related symptoms: After being diagnosed at Veteran General Hospital, Occasional pain of the right costal region and she was transferred to Taipei Taian Hospital for abdomen, tenderness of stomach and pain while unknown treatment. hungry, respiration difficulty, chest stuffiness, edema and swelling of shin Other minor symptoms: Tiredness and weakness, lost of appetite, difficulty in excretion and urination This subject has enrolled into this trial since Aug. 4, 2001 till Sep. 8, 2001 for a total of 3 courses and 36 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On Aug. 16, 2001, after the 1^(st) course, via scan at Determination of efficiency: significant efficiency Taian Hospital, the metastasized tumor has dispersed Filed on Mar. 15, 2002 with normal GOT/GTP. Vesicles in pancreas were blurred due to exudates and kidney function did not deteriorate. On Aug. 26, 2001, main symptoms were significantly alleviated with the gradual dispersion of edema and swelling. The tumor of 2.0 cm at the right liver lobe has dispersed, which indicated the significant efficiency of this trial. However, other treatments performed by the original hospital after such amazing improvement of condition, as well as the weakness of patient, have acted against the “surrounding pathology”. The injection of plasma, preparation of high protein has resulted in the high pressure of portal vein and then led to hepatic coma. Cancer type: hepatoma Name of subject: Mrs. Huang-Ye Gong Original number of case: 98050116 Date of birth: Oct. 10, 1929 The hospital making diagnosis: Kaohsiung Chang Address: Linyuan, Kaohsiung Hsien Gung Hospital Hospital grade: regional (the 2^(nd) grade) Diagnosis method: biopsy and CT and ultrasonic scan Date of diagnosis: Apr. 28, 1998 Place of hospital: Kaohsiung Hsien, Taiwan Diagnosis: multifocal hepatoma (previous rectal cancer was dissected years ago with a normal CEA; all symptoms were referred to be related to hepatoma) Main cancer-related symptoms: Stomach swelling and hardness, local swelling or pain, skin itchiness, and swelling of shin Other minor symptoms: Accustomed constipation with once in 2 or 3 days, weakness of legs, potential sprain and occasional urethritis This subject has enrolled into this trial since May 1, 1998 till Dec. 13, 1998 for a total of 12 courses and 144 days. Trial procedure: The medication combination, specific for treating hepatoma and pancreatic cancer, is taken within 90 minutes after meals, that is 3 times a day for a total of 12 gm. On May 13, 1998, during the course, main symptoms Determination of efficiency: with efficiency were alleviated with gradual dispersion of swelling Filed on Mar. 15, 2002 and vanishment of itchiness. On Jun. 13, 1998, all symptoms were alleviated with the regression of tumor to about 1/2. At the end of treatment, all symptoms were still alleviated but swelling of abdomen and shin was not completely dispersed. 

What is claimed is:
 1. A medication combination for treating hepatoma and pancreatic cancer, comprising Baizhu, Danggui, Hanxincao, Huotanmucao, Ainaxiang, Shuodiao, Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren, Nuzhenzi, Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi, and Banxia.
 2. The medication combination of claim 1, wherein the combination comprises 3-7% of Baizhu, 3-7% of Danggui, 4-8% of Hanxincao, 2-6% of Huotanmucao, 2-6% of Ainaxiang, 5-9% of Shuodiao, 6-10% of Malan, 5-9% of Ludou, 3-7% of Canger, 4-8% of Daqinggen, 3-7% of Banbianlian, 2-6% of Xingren, 4-8% of Nuzhenzi, 3-7% of Qianhu, 3-7% of Jiatonghao, 3-7% of Yinchenhao, 3-7% of Yujin, 2-6% of Zhishi, and 2-6% of Banxia.
 3. The medication combination of claim 2, wherein the combination comprises 5% of Baizhu, 5% of Danggui, 6% of Hanxincao, 4% of Huotanmucao, 4% of Ainaxiang, 7% of Shuodiao, 8% of Malan, 7% of Ludou, 5% of Canger, 6% of Daqinggen, 5% of Banbianlian, 4% of Xingren, 6% of Nuzhenzi, 5% of Qianhu, 5% of Jiatonghao, 5% of Yinchenhao, 5% of Yujin, 5% of Zhishi, and 4% of Banxia.
 4. The medication combination of claim 1 further comprising Fuling as a form of powder.
 5. A medication combination for treating hepatoma and pancreatic cancer comprising: (a) one or more medications selected from the group consisting of Fuling, Baizhu and Danggui for improving the function of pancreas and connections to other organs; (b) one or more medications selected from the group consisting of Hanxincao, Huotanmucao, Ainaxiang and Shuodiao fro eliminating barriers in permeability of the portal vein, liver and pancreas to decrease the pressure of the portal vein; (c) one or more medications selected from the group consisting of Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren and Nuzhenzi for enhancing the defensive function, lymphatic circulation, and immunity, and (d) one or more medications selected from the group consisting of Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi and Banxia for pathological amendments specific for hepatoma and pancreatic cancer.
 6. A method for preparation of a medication combination for treating hepatoma and pancreatic cancer, the method comprising the steps of: mixing concentrated extract powders of Fuling, Baizhu, Danggui, Hanxincao, Huotanmucao, Ainaxiang, Shuodiao, Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren, Nuzhenzi, Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi and Banxia completely by a mixer; blending the mixture with appropriate amount of water; forming the water-contained mixture into tablets by a tablet presser, and drying said tablets for storage.
 7. The method as defined in claim 6, wherein the tablets are dried at a temperature about 45° C.
 8. Thee method as defined in claim 6, wherein the Ludou is concentrated and extracted by the following steps: (a) putting Ludou seeds, which are washed clean and dried previously, into a receiving space formed between two articulations of a bamboo tube through a hole formed on the bamboo tube and communicated with the receiving space, and then sealing the hole for air proof; (b) immersing the sealed bamboo tube into urines of health person for at least 49 days, and then (c) immersing the bamboo tube in a bucket of running spring, said running spring entering the bucket from the bottom of the bucket and overflowing out of the bucket from the top of the bucket, and then (d) immersing the bamboo tube into a water reservoir of running spring with a predetermined volume of tons at least 49 days, said spring water entering the water reservoir from the top of the water reservoir and one-third of the outflow of the running spring flowing out of the water reservoir from the bottom of the water reservoir and two-third of the outflow of the running water overflowing out of the water reservoir from the top of the water reservoir, and then (e) placing said bamboo tube thus obtained form the step (d) on a clean ground and turning said bamboo tube one or twice a day at least 49 days, and then taking the Ludou seeds out of the bamboo tube and screening said Ludou seeds for storage. 